Department of Neurology, Bahcesehir University Medical Faculty, Istanbul, Turkey.
Neurology Department, Erenkoy Mental Health and Neurological Sciences Training and Research Hospital, Istanbul, Turkey.
Acta Neurol Belg. 2020 Oct;120(5):1147-1150. doi: 10.1007/s13760-019-01197-1. Epub 2019 Jul 31.
Parkinson's disease (PD) is a neurodegenerative disorder with motor and non-motor impairment. It has been known for a while that oxidative stress, protein changes and mitochondrial dysfunction have the role of contribution to the pathogenesis. Disturbance of red blood cell function may play a role in the pathophysiology of neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's disease. RDW was found to be strongly associated with inflammatory markers in diseases such as acute pancreatitis, myocardial injury and hepatocellular carcinoma. The data about RDW levels and PD are scarce. In this study, we aimed to investigate the RDW values and their relationship with the severity of the disease in patients with Parkinson's disease. 94 patients with Parkinson's disease were included into the study, 97 healthy individuals without history of PD were considered as control group. The United Parkinson's Disease Rating Scale (UPDRS) and the modified Hoehn and Yahr staging scale were used to assess the severity of PD. Although RDW levels were significantly higher than the healthy subjects, there was not any relation between the severity of PD, duration of the disease, RDW levels, other blood parameters, mean UPDRS score or mean mH&Y score. In conclusion, RDW levels are higher than the healthy subjects in PD patients but there is no relation between RDW levels and disease duration. Larger studies are needed to explain the role of RDW as an inflammatory marker.
帕金森病（PD）是一种具有运动和非运动障碍的神经退行性疾病。众所周知，氧化应激、蛋白质变化和线粒体功能障碍在发病机制中起作用。红细胞功能障碍可能在亨廷顿病、帕金森病和阿尔茨海默病等神经退行性疾病的病理生理学中起作用。RDW 被发现与急性胰腺炎、心肌损伤和肝细胞癌等疾病中的炎症标志物密切相关。关于 RDW 水平与 PD 的相关数据很少。在这项研究中，我们旨在探讨 RDW 值及其与帕金森病患者疾病严重程度的关系。研究纳入 94 例帕金森病患者，97 例无 PD 病史的健康个体作为对照组。采用统一帕金森病评定量表（UPDRS）和改良 Hoehn 和 Yahr 分期量表评估 PD 的严重程度。虽然 RDW 水平明显高于健康受试者，但 PD 的严重程度、疾病持续时间、RDW 水平、其他血液参数、平均 UPDRS 评分或平均 mH&Y 评分之间均无相关性。总之，PD 患者的 RDW 水平高于健康受试者，但 RDW 水平与疾病持续时间之间无相关性。需要更大的研究来解释 RDW 作为炎症标志物的作用。
