Faculty of Chemistry, Ho Chi Minh City University of Pedagogy, Ho Chi Minh City, Vietnam.
Faculty of Chemistry, VNUHCM-University of Science, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2021 Apr;35(7):1192-1198. doi: 10.1080/14786419.2019.1641806. Epub 2019 Aug 1.
From remaining aqueous fraction of the roots of , one new cardiac glycoside named periplogenin 3---gentiobioside () together with six known ones () were isolated. Their relative structures were elucidated based on NMR spectroscopic analysis. Compound showed moderate cytotoxicity against non-small cell lung carcinoma NCI-H460 and ovarian cancer HeLa cells. Moreover, compounds and exhibited remarkable cytotoxicity against NCI-H460 cell with the IC values of 0.34 and 0.068 M, respectively.
从 的根的剩余水相部分中，分离得到一种新的强心苷，命名为periplogenin 3---龙胆二糖苷（），以及六种已知的化合物（）。基于 NMR 光谱分析确定了它们的相对结构。化合物 对非小细胞肺癌 NCI-H460 和卵巢癌细胞 HeLa 具有中等的细胞毒性。此外，化合物 和 对 NCI-H460 细胞表现出显著的细胞毒性，IC 值分别为 0.34 和 0.068M。
