Ter Borg E J, Van der Meer J, De Wolf J T, Van Leeuwen M H, Kallenberg C G
Department of Internal Medicine, University Hospital, Groningen, The Netherlands.
Clin Rheumatol. 1988 Mar;7(1):74-9. doi: 10.1007/BF02284060.
To demonstrate the wide variety of clinical syndromes associated with the lupus anticoagulant (LAC), we report the case histories of three young females with arterial thrombosis in whom LAC was demonstrated. Two patients had a diagnosis of systemic lupus erythematosus and mixed connective tissue disease respectively; the other patient had no signs of underlying auto-immune disease. Arterial thrombotic events in young females should arouse suspicion of the presence of LAC although its pathophysiological significance is not established.
为了证明与狼疮抗凝物（LAC）相关的临床综合征的多样性，我们报告了3例确诊为LAC的年轻女性动脉血栓形成的病例。其中2例患者分别诊断为系统性红斑狼疮和混合性结缔组织病；另1例患者无潜在自身免疫性疾病的迹象。尽管LAC的病理生理意义尚未明确，但年轻女性发生动脉血栓事件时应怀疑LAC的存在。
