Takahashi M, Shumiya S, Maekawa A, Hayashi Y, Nagase S
Department of Chemistry, Sasaki Institute, Tokyo.
Jpn J Cancer Res. 1988 Jun;79(6):705-9. doi: 10.1111/j.1349-7006.1988.tb02226.x.
The susceptibility of an analbuminemic congenic strain of rats (F344-alb) originating from the F344 strain to N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was examined. F344-alb rats were found to be highly susceptible to induction of urinary bladder cancers. The incidences of bladder cancers in F344-alb and F344 rats were 94% (15/16) and 31% (5/16) in males and 100% (16/16) and 19% (3/16) in females. The bladder weights of these rats, including tumors, were 307 +/- 294 mg, 123 +/- 26 mg, 183 +/- 80 mg and 93 +/- 11 mg, respectively. Administration of 0.05%, 0.1% and 0.3% BBN in the drinking water for 2 weeks resulted in greater increases in the bladder content of N-butyl-N-(3-carboxypropyl)nitrosamine in F344-alb rats than in F344 rats. This increase was prevented by the presence of rat albumin.
研究了源自F344品系的无白蛋白同基因大鼠品系（F344-alb）对N-丁基-N-（4-羟基丁基）亚硝胺（BBN）的易感性。发现F344-alb大鼠对膀胱癌的诱导高度敏感。F344-alb和F344大鼠中膀胱癌的发生率在雄性中分别为94%（15/16）和31%（5/16），在雌性中分别为100%（16/16）和19%（3/16）。这些大鼠（包括有肿瘤的大鼠）的膀胱重量分别为307±294毫克、123±26毫克、183±80毫克和93±11毫克。在饮用水中给予0.05%、0.1%和0.3%的BBN两周后，F344-alb大鼠膀胱中N-丁基-N-（3-羧丙基）亚硝胺的含量比F344大鼠增加得更多。大鼠白蛋白的存在可阻止这种增加。
