5-甲氧基补骨脂素的抗抑郁作用：初步报告。
Antidepressant effect of 5-methoxypsoralen: a preliminary report.
作者信息
Souêtre E, Salvati E, Belugou J L, Robert P, Brunet G, Darcourt G
机构信息
Clinique de Psychiatrie et de Psychologie Medicale, Hôpital Pasteur, Nice, France.
出版信息
Psychopharmacology (Berl). 1988;95(3):430-1. doi: 10.1007/BF00181962.
5-Methoxypsoralen (5 MOP) administered daily (40 mg at 9 p.m.) was compared with placebo in the treatment of severe depression. The clinical response was evaluated using the Hamilton Depression Rating Scale after 1 week of treatment. Our preliminary data indicate that patients receiving 5 MOP improved significantly after 1 week, whereas patients treated with placebo did not. The stimulating effect of 5 MOP on the melatonin secretion may be involved in this clinical effect.
将每日（晚上9点服用40毫克）服用的5-甲氧基补骨脂素（5-MOP）与安慰剂进行对比，用于治疗重度抑郁症。治疗1周后，使用汉密尔顿抑郁量表评估临床反应。我们的初步数据表明，接受5-MOP治疗的患者在1周后有显著改善，而接受安慰剂治疗的患者则没有。5-MOP对褪黑素分泌的刺激作用可能与这种临床效果有关。
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