Center for Stem Cell Therapeutics and Imaging (CSTI), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Stem Cells. 2020 Jan;38(1):34-44. doi: 10.1002/stem.3069. Epub 2019 Aug 21.
Multiple stem cell types exhibit inherent tropism for cancer, and engineered stem cells have been used as therapeutic agents to specifically target cancer cells. Recently, stem cells have been engineered to target multiple surface receptors on tumor cells, as well as endothelial and immune cells in the tumor microenvironment. In this review, we discuss the rationales and strategies for developing multiple receptor-targeted stem cells, their mechanisms of action, and the promises and challenges they hold as cancer therapeutics.
多种干细胞类型对癌症具有固有趋向性，经过工程改造的干细胞已被用作治疗剂，以专门针对癌细胞。最近，已经对干细胞进行了工程改造，以靶向肿瘤细胞上的多个表面受体，以及肿瘤微环境中的内皮细胞和免疫细胞。在这篇综述中，我们讨论了开发多受体靶向干细胞的原理和策略、它们的作用机制，以及它们作为癌症治疗剂的前景和挑战。
