Lee Michael D
Exobiology Branch, NASA Ames Research Center, Moffett Field, CA, USA.
Evol Bioinform Online. 2019 Jul 25;15:1176934319862245. doi: 10.1177/1176934319862245. eCollection 2019.
Phylogenomics is the practice of attempting to infer evolutionary relationships at a genome-level. This is becoming a standard step in the characterization of newly recovered genomes and to direct/constrain further research; yet the process from start to finish of building a de novo phylogenomic tree that is specific to the organisms of interest can still be computationally intractable for many biologists. GToTree is a recently published user-friendly workflow for phylogenomics intended to give more researchers the capability to generate phylogenomic trees to help guide their work. This commentary describes two common applications where GToTree can be helpful and then discusses some things to consider when using the program.
系统发育基因组学是一种试图在基因组水平上推断进化关系的实践方法。这正成为新获得基因组特征描述中的一个标准步骤，并用于指导/限制进一步的研究；然而，对于许多生物学家来说，从头构建一棵特定于感兴趣生物体的系统发育基因组树，从开始到结束的过程在计算上仍然难以处理。GToTree是最近发布的一个用户友好的系统发育基因组学工作流程，旨在让更多研究人员有能力生成系统发育基因组树来指导他们的工作。本评论描述了GToTree可能有用的两个常见应用，然后讨论了使用该程序时需要考虑的一些事项。
