促进初级保健中的筛查和简短干预:AUDIT 作为酒精使用障碍指标的系统评价和荟萃分析。

Facilitating Screening and Brief Interventions in Primary Care: A Systematic Review and Meta-Analysis of the AUDIT as an Indicator of Alcohol Use Disorders.

机构信息

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

出版信息

Alcohol Clin Exp Res. 2019 Oct;43(10):2028-2037. doi: 10.1111/acer.14171. Epub 2019 Aug 23.

Abstract

BACKGROUND

The Alcohol Use Disorders Identification Test (AUDIT) was developed for use in primary health care settings to identify hazardous and harmful patterns of alcohol consumption, and is often used to screen for alcohol use disorders (AUDs). This study examined the AUDIT as a screening tool for AUDs.

METHODS

A systematic literature search was performed of electronic bibliographic databases (CINAHL, Embase, ERIC, MEDLINE, PsycINFO, Scopus, and Web of Science) without language or geographic restrictions for original quantitative studies published before September 1, 2018, that assess the AUDIT's ability to screen for AUDs. Random-effects meta-regression models were constructed by sex to assess the potential determinants of the AUDIT's specificity and sensitivity. From these models and ecological data from the Global Information System on Alcohol and Health, the true- and false-positive and true- and false-negative proportions were determined. The number of people needed to be screened to treat 1 individual with an AUD was estimated for all countries globally where AUD data exist, using a specificity of 0.95.

RESULTS

A total of 36 studies met inclusion criteria for the meta-regression. The AUDIT score cut-point was significantly associated with sensitivity and specificity. Standard drink size was found to affect the sensitivity and specificity of the AUDIT for men, but not among women. The AUDIT performs less well in identifying women compared to men, and countries with a low prevalence of AUDs have higher false-positive rates compared to countries with a higher AUD prevalence.

CONCLUSIONS

The AUDIT does not perform well as a screening tool for identifying individuals with an AUD, especially in countries and among populations with a low AUD prevalence (e.g., among women), and thus should not be used for this purpose.

摘要

背景

酒精使用障碍识别测试(AUDIT)是为初级保健环境开发的,用于识别危险和有害的饮酒模式,常用于筛查酒精使用障碍(AUD)。本研究考察了 AUDIT 作为 AUD 筛查工具的性能。

方法

系统检索了电子文献数据库(CINAHL、Embase、ERIC、MEDLINE、PsycINFO、Scopus 和 Web of Science),未设语言或地域限制,检索了截至 2018 年 9 月 1 日以前发表的评估 AUDIT 筛查 AUD 能力的原始定量研究。构建了按性别分层的随机效应荟萃回归模型,以评估 AUDIT 特异性和敏感性的潜在决定因素。从这些模型和全球酒精与健康信息系统的生态学数据中,确定了真阳性和假阳性、真阴性和假阴性的比例。使用特异性为 0.95,估计了所有存在 AUD 数据的国家中,为治疗 1 例 AUD 患者所需的筛查人数。

结果

共有 36 项研究符合荟萃回归的纳入标准。AUDIT 评分切点与敏感性和特异性显著相关。发现标准饮酒量会影响 AUDIT 对男性的敏感性和特异性,但对女性没有影响。与男性相比,AUDIT 识别女性的效果较差,AUD 患病率较低的国家的假阳性率高于 AUD 患病率较高的国家。

结论

AUDIT 作为识别 AUD 患者的筛查工具效果不佳,特别是在 AUD 患病率较低的国家和人群(例如女性)中,因此不应将其用于此目的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9de7/6852009/d022af67cf13/ACER-43-2028-g001.jpg

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