Kushwaha Arvind Singh, Kotwal Atul, Biradar C I, Kumar Mahadevan, Pawar Shailesh D, Chadha Mandeep, Patrikar Seema
Additional Professor (Community Medicine), AIIMS Nagpur, India.
Brig Medical, HQ 11 Corps, C/o 56 APO, India.
Med J Armed Forces India. 2019 Jul;75(3):312-317. doi: 10.1016/j.mjafi.2018.08.003. Epub 2019 Jun 4.
Various serosurveys and studies were conducted globally on pandemic influenza. H1N1 virus reported so far provides ample evidence of differing perspectives, regarding its epidemiology especially with regard to prevalence, populations groups, and behaviour related to vaccine acceptance. A multigroup, cross-sectional survey among 658 healthy subjects was carried out, in Pune among students, health-care workers (HCWs), and soldiers to assess the seroprevalence of pandemic influenza H1N1 virus and its associated factors.
The total sample size, based on forecasted prevalence of 33%, worked out to be 640. We studied 658 subjects including 103 students, 201 HCWs, and 354 serving soldiers. The sample for each group was selected from the respective study population by simple random sampling using a random number table. Haemagglutination inhibition test was carried out at the National Institute of Virology.
The overall seroprevalence of pandemic influenza H1N1 (2009) virus was found to be 46.5% (95% confidence interval 42.6-50.4) which was adjusted to 39.4% after excluding those vaccinated. The availability of vaccine for high-risk group such as HCWs did not find much favour with the HCWs who did not accept vaccine for various reasons. Whereas only one student was vaccinated, 21.4% of HCWs and 32.5% of soldiers were vaccinated.
Based on high seroprevalence of antibodies against H1N1 virus during pandemic, vaccination of general population is not recommended. However, high-risk groups and HCWs need to be protected with flu vaccine. There is a need to encourage HCWs for accepting vaccination.
全球针对甲型H1N1流感大流行开展了各种血清学调查和研究。目前报告的甲型H1N1流感病毒在其流行病学方面，尤其是在流行率、人群分组以及与疫苗接受度相关行为等方面，提供了大量不同观点的证据。在印度浦那对658名健康受试者（包括学生、医护人员和士兵）进行了一项多组横断面调查，以评估甲型H1N1流感大流行病毒的血清流行率及其相关因素。
根据预测的33%流行率计算，总样本量应为640。我们研究了658名受试者，包括103名学生、201名医护人员和354名现役士兵。每组样本通过使用随机数表的简单随机抽样从各自的研究人群中选取。血凝抑制试验在国家病毒学研究所进行。
发现甲型H1N1（2009）流感大流行病毒的总体血清流行率为46.5%（95%置信区间42.6 - 50.4），排除接种疫苗者后调整为39.4%。医护人员等高风险群体可获得疫苗，但因各种原因不接受疫苗的医护人员对此并不感兴趣。只有一名学生接种了疫苗，而21.4%的医护人员和32.5%的士兵接种了疫苗。
基于大流行期间针对H1N1病毒抗体的高血清流行率，不建议对普通人群进行疫苗接种。然而，高风险群体和医护人员需要接种流感疫苗进行保护。有必要鼓励医护人员接受疫苗接种。
