Düzel Emrah, Acosta-Cabronero Julio, Berron David, Biessels Geert Jan, Björkman-Burtscher Isabella, Bottlaender Michel, Bowtell Richard, Buchem Mark V, Cardenas-Blanco Arturo, Boumezbeur Fawzi, Chan Dennis, Clare Stuart, Costagli Mauro, de Rochefort Ludovic, Fillmer Ariane, Gowland Penny, Hansson Oskar, Hendrikse Jeroen, Kraff Oliver, Ladd Mark E, Ronen Itamar, Petersen Esben, Rowe James B, Siebner Hartwig, Stoecker Tony, Straub Sina, Tosetti Michela, Uludag Kamil, Vignaud Alexandre, Zwanenburg Jaco, Speck Oliver
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Magdeburg, Germany.
Alzheimers Dement (Amst). 2019 Jul 31;11:538-549. doi: 10.1016/j.dadm.2019.04.010. eCollection 2019 Dec.
The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists.
EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization.
The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials.
The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.
欧洲神经退行性疾病超高场成像网络（EUFIND）的目标是确定7特斯拉（7T）磁共振成像（MRI）在神经退行性疾病临床和研究应用中的机遇与挑战。EUFIND包括22个欧洲站点和1个美国站点，有50多位MRI和痴呆症专家以及神经科学家。
EUFIND结合了共识研讨会和数据共享以进行多站点分析，重点关注7个核心主题：临床应用/临床研究、最高分辨率解剖结构、功能成像、血管系统/血管病理学、铁成像和神经病理学检测、光谱学以及质量保证。在这些主题中，EUFIND考虑了标准操作程序、安全性和多厂商协调。
7T MRI在每个子主题中的临床和研究机遇与挑战被整理成路线图。本报告中展示的一项初步研究实施了每个子主题的特定MRI序列。结果表明，拥有高度先进且协调一致的成像序列的大型多站点7T成像网络是可行的，并且可能推动未来的多中心超高场MRI研究和临床试验。
EUFIND网络可以成为推进使用7T的临床神经成像研究以及确定神经退行性疾病临床应用用例的主要驱动力。
