Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.
Biomech Model Mechanobiol. 2020 Feb;19(1):263-273. doi: 10.1007/s10237-019-01209-2. Epub 2019 Aug 6.
Cardiac growth is the natural capability of the heart to change size in response to changes in blood flow demand of the growing body. Cardiac diseases can trigger the same process leading to an abnormal type of growth. Prediction of cardiac growth would be clinically valuable, but so far published models on cardiac growth differ with respect to the stimulus-effect relation and constraints used for maximum growth. In this study, we use a zero-dimensional, multiscale model of the left ventricle to evaluate cardiac growth in response to three valve diseases, aortic and mitral regurgitation along with aortic stenosis. We investigate how different combinations of stress- and strain-based stimuli affect growth in terms of cavity volume and wall volume and hemodynamic performance. All of our simulations are able to reach a converged state without any growth constraint, with the most promising results obtained while considering at least one stress-based stimulus. With this study, we demonstrate how a simple model of left ventricular mechanics can be used to have a first evaluation on a designed growth law.
心脏生长是心脏根据身体血流需求变化而改变大小的自然能力。心脏疾病可触发相同的过程，导致异常类型的生长。心脏生长的预测具有重要的临床价值，但迄今为止，发表的心脏生长模型在用于最大生长的刺激-效应关系和约束方面存在差异。在这项研究中，我们使用左心室的零维多尺度模型来评估三种瓣膜疾病（主动脉瓣和二尖瓣反流以及主动脉瓣狭窄）对心脏生长的影响。我们研究了不同的基于应力和应变的刺激组合如何影响腔室体积和壁体积以及血液动力学性能的生长。我们所有的模拟都能够在没有任何生长约束的情况下达到收敛状态，而在考虑至少一种基于应力的刺激时，得到了最有希望的结果。通过这项研究，我们展示了如何使用左心室力学的简单模型对设计的生长规律进行初步评估。
