Ngamsamer Chanya, Sirivarasai Jintana, Sutjarit Nareerat
Doctor of Philosophy Program in Nutrition, Faculty of Medicine, Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok, 10400, Thailand.
Graduate Program in Nutrition, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Biomolecules. 2022 Jun 20;12(6):852. doi: 10.3390/biom12060852.
Obesity has become a serious public health epidemic because of its associations with chronic conditions such as type 2 diabetes mellitus, hypertension, cardiovascular disease, and cancer. Obesity triggers inflammation marked by the secretion of low-grade inflammatory cytokines including interleukin-6, C-reactive protein, and tumor necrosis factor-α, leading to a condition known as "meta-inflammation". Currently, there is great interest in studying the treatment of obesity with food-derived bioactive compounds, which have low toxicity and no severe adverse events compared with pharmacotherapeutic agents. Here, we reviewed the beneficial effects of the bioactive compounds known as anthocyanins on obesity-induced inflammation. Foods rich in anthocyanins include tart cherries, red raspberries, black soybeans, blueberries, sweet cherries, strawberries and Queen Garnet plums. These anthocyanin-rich foods have been evaluated in cell culture, animal, and clinical studies, and found to be beneficial for health, reportedly reducing inflammatory markers. One factor in the development of obesity-related inflammation may be dysbiosis of the gut microbiome. Therefore, we focused this review on the in vitro and in vivo effects of anthocyanins on inflammation and the gut microbiota in obesity.
肥胖已成为一种严重的公共卫生流行病，因为它与2型糖尿病、高血压、心血管疾病和癌症等慢性疾病相关联。肥胖引发炎症，其特征是分泌包括白细胞介素-6、C反应蛋白和肿瘤坏死因子-α在内的低度炎性细胞因子，导致一种被称为“代谢性炎症”的状况。目前，人们对研究用食物来源的生物活性化合物治疗肥胖非常感兴趣，与药物治疗剂相比，这些化合物毒性低且无严重不良事件。在此，我们综述了被称为花青素的生物活性化合物对肥胖诱导炎症的有益作用。富含花青素的食物包括酸樱桃、红树莓、黑豆、蓝莓、甜樱桃、草莓和王后石榴李。这些富含花青素的食物已在细胞培养、动物和临床研究中进行了评估，发现对健康有益，据报道可降低炎症标志物。肥胖相关炎症发展的一个因素可能是肠道微生物群失调。因此，我们将本综述的重点放在花青素对肥胖炎症和肠道微生物群的体外和体内作用上。
