Key Laboratory of Catalysis and Material Sciences of the State Ethnic Affairs Commission & Ministry of Education, College of Chemistry and Material Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, Chemical Biology Center, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16729-16735. doi: 10.1073/pnas.1908761116. Epub 2019 Aug 7.
Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemo-photothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.
离散型 Pt(II) 金属络合物在生物医药中有潜在的应用。在此，我们设计了一种双模式成像和化学光热治疗的纳米制剂 1，它将离散型 Pt(II) 金属络合物 2 和荧光染料 3（发射波长在第二个近红外通道[NIR-II]）整合到具有光声信号和光热特性的多功能黑色素点中。纳米制剂 1 在体内具有良好的溶解性、生物相容性和稳定性。体内的光声成像和近红外二区成像都证实 1 可以有效地在肿瘤部位积累，具有良好的信噪比和良好的分布。在精确的双模式成像的指导下，纳米制剂 1 表现出优于单一治疗的抗肿瘤性能和较小的副作用，因为化学光热协同治疗的效率很高。本研究表明，纳米制剂 1 为潜在的生物医药应用提供了一个有前途的多功能治疗平台。
