School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
J Ethnopharmacol. 2019 Dec 5;245:112147. doi: 10.1016/j.jep.2019.112147. Epub 2019 Aug 8.
Ilex pubescens (I. pubescens), which is well known in Chinese as Mao-Dong-Qing, is widely used in traditional Chinese medicine. This plant is distributed in the wild in southern China, and the roots and stems are used for clearing heat, detoxifying, activating blood circulation and dispelling stasis. Moreover, it is used for treating wind-heat cold, lung-heat asthma, swelling and pain of pharynxes and gingivae, thoracic obstruction and cardiodynia with pungent, stroke, hemiplegia, thromboangiitis obliterans, burn, scald and central retinitis.
This paper aims to provide a critical summary of the current studies on I. pubescens. The progress in research on the botany, traditional uses, phytochemistry, pharmacology and toxicology of the plant is discussed. We mainly focus on the phytochemical and pharmacological investigations of I. pubescens. Furthermore, perspectives for possible future studies on I. pubescens are also discussed.
A systematic review was conducted on the studies of I. pubescens performed during the past 40 years with resources including the Chinese Pharmacopoeia and literature databases such as PubMed, Science Direct, Wiley, CNKI (China National Knowledge Infrastructure), SciFinder, Web of Science, Google Scholar and Baidu Scholar.
To date, more than 200 compounds have been isolated and identified from the plant, a substantial proportion of which were reported to be triterpenes. Biological effects such as protective effects against cardio-cerebrovascular diseases, anti-thrombosis, anti-inflammatory and anti-tumour activities were also investigated in in vitro and in vivo research. Therapeutic effects are attributed to the bioactivities of the naturally occurring compounds in this herb. Furthermore, toxicological studies on I. pubescens are relatively scarce, and it is worthy of further research.
This review summarizes the results from current studies of I. pubescens, which is one of the valuable medicinal sources from traditional herbs. Some conventional uses have been evaluated by pharmacological investigation. In addition, unresolved issues include molecular mechanisms underlying bioactivities, pharmacokinetics, toxicology and efficacy, which are still being studied and explored before achieving integration into clinical medicines.
毛冬青（I. pubescens），在中国被广泛称为“猫冬清”，是一种传统中药。该植物在中国南方野外分布，其根和茎用于清热、解毒、活血、化瘀。此外，它还用于治疗风热感冒、肺热哮喘、咽喉肿痛、胸痹心痛、中风偏瘫、血栓闭塞性脉管炎、烧伤、烫伤、中心性视网膜炎。
本文旨在对毛冬青的现有研究进行批判性总结。讨论了该植物的植物学、传统用途、植物化学、药理学和毒理学研究进展。我们主要关注毛冬青的植物化学和药理学研究进展。此外，还讨论了毛冬青未来可能的研究方向。
对过去 40 年毛冬青研究的文献进行系统综述，资源包括《中国药典》和文献数据库，如 PubMed、Science Direct、Wiley、CNKI（中国国家知识基础设施）、SciFinder、Web of Science、Google Scholar 和百度学术。
迄今为止，已从该植物中分离鉴定出 200 多种化合物，其中相当一部分为三萜类化合物。在体外和体内研究中还研究了其对心脑血管疾病的保护作用、抗血栓形成、抗炎和抗肿瘤活性等生物效应。治疗作用归因于该草药中天然存在化合物的生物活性。此外，毛冬青的毒理学研究相对较少，值得进一步研究。
本综述总结了毛冬青现有研究的结果，毛冬青是传统草药中一种有价值的药用资源。一些传统用途已通过药理学研究进行了评估。此外，生物活性的分子机制、药代动力学、毒理学和疗效等尚未解决的问题仍在研究和探索中，在将其整合到临床药物之前仍需进一步研究。
