Ramos-Payán María
Department of Analytical Chemistry, Faculty of Chemistry, University of Seville, c/Prof. García González s/n, 41012, Seville, Spain.
Anal Chim Acta. 2019 Nov 8;1080:12-21. doi: 10.1016/j.aca.2019.05.075. Epub 2019 Jun 1.
This tutorial discusses how to integrate different microextraction procedures into millifluidic platforms and the applicability of such systems for the determination of acidic and basic drugs. Sample preparation techniques have been downscaled into a millifluidic format and the replacement of conventional analytical systems by miniaturized alternatives has increased during recent years due to the small volume consumption of toxic solvents and sample required, shorter extraction times, simple-handling and low cost, among others. This review comprehensively summarizes the development of liquid-liquid extraction into a millifluidic device in a three-phase configuration, with focus on (a) historical development, (b) extraction mechanisms and performance, (c) operation modes and automatization, (d) operational parameters, (e) applications, and (f) future directions and perspectives.
本教程讨论了如何将不同的微萃取程序集成到微流控平台中，以及此类系统在酸性和碱性药物测定中的适用性。近年来，由于有毒溶剂和所需样品的消耗量小、萃取时间短、操作简单且成本低等原因，样品制备技术已被缩小到微流控形式，并且微型替代系统取代传统分析系统的情况有所增加。本综述全面总结了液-液萃取在三相配置的微流控装置中的发展，重点关注：（a）历史发展；（b）萃取机制和性能；（c）操作模式和自动化；（d）操作参数；（e）应用；以及（f）未来方向和前景。
