Varaldo P E, Biavasco F, Mannelli S, Pompei R, Proietti A
Institute of Microbiology, University of Ancona Medical School, Italy.
Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):495-500. doi: 10.1007/BF01962599.
A total of 451 extraintestinal, clinically relevant strains of the Klebsiella, Enterobacter and Serratia spp. isolated over a nine-month period from hospitalized patients at four different centers in Italy were investigated. Identification using the API 20E system showed that isolates belonged to 12 different species. Overall, strains of Klebsiella, Enterobacter and Serratia were in a ratio of approximately 3.4:2:1. Fifty-nine per cent of all strains were from urinary specimens, 12% from respiratory secretions, 10% from wounds and abscesses, and lower percentages from other sources. All strains were tested for their susceptibility to ten antibiotics. The rate of resistance to most drugs was generally greater in Enterobacter and Serratia than in Klebsiella. The overall incidence of strains of the intermediate category (i.e. between full sensitivity and resistance) was unexpectedly high. Both the relative frequency and the antibiotic susceptibility of strains of the various species varied from center to center; possible reasons for such differences are examined.
对在九个月期间从意大利四个不同中心的住院患者中分离出的总共451株肠道外、具有临床相关性的克雷伯菌属、肠杆菌属和沙雷菌属菌株进行了研究。使用API 20E系统进行鉴定显示，分离株属于12个不同的物种。总体而言，克雷伯菌属、肠杆菌属和沙雷菌属菌株的比例约为3.4:2:1。所有菌株中有59%来自尿液标本，12%来自呼吸道分泌物，10%来自伤口和脓肿，其他来源的比例较低。对所有菌株进行了对十种抗生素的敏感性测试。肠杆菌属和沙雷菌属对大多数药物的耐药率通常高于克雷伯菌属。中间类别（即介于完全敏感和耐药之间）菌株的总体发生率出乎意料地高。不同物种菌株的相对频率和抗生素敏感性因中心而异；研究了造成这种差异的可能原因。
