Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, United States; National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA 30341, United States.
National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA 30341, United States; Oak Ridge Institute for Science and Education, 100 ORAU Way, Oak Ridge, TN 37830, United States.
Reprod Toxicol. 2019 Dec;90:8-14. doi: 10.1016/j.reprotox.2019.08.003. Epub 2019 Aug 12.
Perfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight-related outcomes. Previous studies observed an association between perfluorooctane sulfonic acid (PFOS) and higher gestational weight gain among under-/normal weight mothers. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG) using data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children. Women were routinely weighed in antenatal check-ups; absolute GWG was determined by subtracting the first weight measurement from the last. Linear regression was used to explore associations of maternal PFAS concentrations with absolute GWG, stratified by prepregnancy body mass index. Associations of maternal PFOS, perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) concentrations with absolute GWG were null; 10% higher PFOS was associated with GWG of -0.03 kg (95% CI: -0.11, 0.06) among under-/normal weight mothers. Ten percent higher perfluorononanoic acid (PFNA) was associated with a higher GWG of 0.09 kg (95% CI: 0.02, 0.16) among under-/normal weight mothers. Overall, findings suggest no association between maternal PFOA, PFOS, and PFHxS concentrations and GWG, and a weak positive association between maternal PFNA and GWG.
全氟烷基物质 (PFAS) 是用于制造消费品的化学物质。PFAS 可能作为内分泌干扰物，影响代谢途径和与体重相关的结果。先前的研究观察到全氟辛烷磺酸 (PFOS) 与低体重/正常体重母亲的妊娠体重增加之间存在关联。我们使用雅芳纵向父母和儿童研究的一个子样本中的 905 名女性的妊娠血清妊娠浓度数据来分析母体血清妊娠浓度与妊娠体重增加 (GWG) 的关联。女性在产前检查中常规称重；绝对 GWG 通过从最后一次测量中减去第一次测量来确定。线性回归用于探索母体 PFAS 浓度与绝对 GWG 的关联，按孕前体重指数分层。母体 PFOS、全氟辛酸 (PFOA) 和全氟己烷磺酸 (PFHxS) 浓度与绝对 GWG 的关联为零；低体重/正常体重母亲中，PFOS 浓度每增加 10%，GWG 减少 0.03 公斤（95%CI：-0.11，0.06）。母体全氟壬酸 (PFNA) 浓度每增加 10%，低体重/正常体重母亲的 GWG 增加 0.09 公斤（95%CI：0.02，0.16）。总体而言，研究结果表明，母体 PFOA、PFOS 和 PFHxS 浓度与 GWG 之间没有关联，而母体 PFNA 与 GWG 之间存在微弱的正相关。
