Miller E J, Lee C A, Karayiannis P, Hamilton-Dutoit S J, Dick R, Thomas H C, Kernoff P B
Academic Department of Haematology, Royal Free Hospital School of Medicine, London.
J Clin Pathol. 1988 Oct;41(10):1039-43. doi: 10.1136/jcp.41.10.1039.
Liver biopsy specimens previously taken from 16 haemophilic patients with chronic non-A, non-B hepatitis were reviewed. The degree of fibrosis correlated with serum procollagen III peptide (sPIIIP) concentrations, measured both at the time of biopsy and 4.25 years later. Two patients with extremely high sPIIIP concentrations had collateral veins on computed tomography, suggesting portal hypertension. Twenty eight of 47 patients (60%) had splenomegaly on computed tomography, and of 28 patients in whom intravenous contrast medium was used, seven (25%) had collateral oesophageal veins. Serum procollagen III peptide estimations and computed tomography, both non-invasive investigations, indicated that hepatic fibrosis and portal hypertension had developed in a proportion of haemophilic patients with non-A, non-B hepatitis. Infection with the human immunodeficiency virus (HIV) may modify the course of this presumably cytopathic virus infection of the liver.
回顾了之前从16例患有慢性非甲非乙型肝炎的血友病患者身上获取的肝活检标本。纤维化程度与活检时及4.25年后测量的血清Ⅲ型前胶原肽（sPIIIP）浓度相关。两名sPIIIP浓度极高的患者在计算机断层扫描上出现了侧支静脉，提示门静脉高压。47例患者中有28例（60%）在计算机断层扫描上出现脾肿大，在28例使用静脉造影剂的患者中，7例（25%）出现食管侧支静脉。血清Ⅲ型前胶原肽测定和计算机断层扫描这两项非侵入性检查表明，一部分患有非甲非乙型肝炎的血友病患者出现了肝纤维化和门静脉高压。人类免疫缺陷病毒（HIV）感染可能会改变这种可能由细胞病变病毒引起的肝脏感染病程。
