Surrenti C, Casini A, Milani S, Ambu S, Ceccatelli P, D'Agata A
Dig Dis Sci. 1987 Jul;32(7):705-9. doi: 10.1007/BF01296135.
Serum N-terminal procollagen type III peptide (sPIIIP) levels were evaluated in 58 patients affected by chronic liver disease, in order to assess the usefulness of sPIIIP as a marker of hepatic fibrosis. In 45 patients sPIIIP was also correlated to liver histology; biopsies were scored by two of the authors, without knowledge of diagnosis. Compared to normal controls, sPIIIP concentration was found to be significantly elevated in chronic active hepatitis (CAH) and in cirrhosis, but not in fatty liver. Patients affected by chronic persistent hepatitis (CPH) had values of sPIIIP higher than normal in four of 11 cases considered. A close correlation was found between sPIIIP values and histological parameters of inflammation, necrosis, and degeneration, while the relationship between sPIIIP levels and fibrosis was weaker. These data suggest that sPIIIP determination may reflect the extent of inflammatory changes in the liver; but it cannot be considered a reliable index of hepatic fibrosis.
对58例慢性肝病患者的血清III型前胶原氨基端肽（sPIIIP）水平进行了评估，以评估sPIIIP作为肝纤维化标志物的实用性。在45例患者中，sPIIIP还与肝脏组织学相关；活检由两位作者进行评分，他们对诊断不知情。与正常对照组相比，发现慢性活动性肝炎（CAH）和肝硬化患者的sPIIIP浓度显著升高，但脂肪肝患者未升高。在11例慢性持续性肝炎（CPH）患者中，有4例患者的sPIIIP值高于正常。发现sPIIIP值与炎症、坏死和变性的组织学参数密切相关，而sPIIIP水平与纤维化之间的关系较弱。这些数据表明，sPIIIP测定可能反映肝脏炎症变化的程度；但它不能被视为肝纤维化的可靠指标。
