S. Cowan, E. Leeming, A. Sinclair, A. Dordevic, H. Truby, and S. Gibson are with the Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia.
Nutr Rev. 2020 Jan 1;78(1):19-38. doi: 10.1093/nutrit/nuz030.
Reduction of subclinical inflammation is a potential target for chronic disease management. Adiposity is a known modifier of meta-inflammation; however, the influence of dietary factors is less clear.
This review examines evidence from human trials evaluating effects of whole foods or dietary patterns on circulating inflammatory markers in weight-stable overweight and obese adults. It is the first review to investigate effects of diet on inflammation, independent of changes in adiposity.
The Ovid MEDLINE, EMBASE, CINAHL, and Cochrane databases were searched.
Data extraction was conducted using the Cochrane Collaboration Handbook for Systematic Reviews of Interventions.
Study quality was evaluated using the Cochrane Collaboration Risk of Bias Assessment tool. Thirty-three studies were included assessing effects of 17 foods and dietary patterns on 39 inflammatory markers.
Overall, foods and dietary patterns were not found to have significant effects on inflammatory markers in weight-stable individuals. Inconsistencies among studies were largely due to methodological limitations. Future research should invest in longer intervention periods and standardization of inflammatory marker panels paired with novel technologies, while ensuring anthropometric measures are monitored and adequately controls are used.
Prospero registration number CRD42017067765.
减轻亚临床炎症是慢性病管理的一个潜在目标。肥胖是已知的代谢炎症调节剂；然而，饮食因素的影响尚不清楚。
本综述检查了评估全食物或饮食模式对体重稳定超重和肥胖成年人循环炎症标志物影响的人体试验证据。这是第一篇独立于肥胖变化研究饮食对炎症影响的综述。
在 Ovid MEDLINE、EMBASE、CINAHL 和 Cochrane 数据库中进行了检索。
使用 Cochrane 协作组干预系统评价手册进行了数据提取。
使用 Cochrane 协作组偏倚风险评估工具评估了研究质量。纳入了 33 项研究，评估了 17 种食物和饮食模式对 39 种炎症标志物的影响。
总体而言，在体重稳定的个体中，食物和饮食模式并未发现对炎症标志物有显著影响。研究之间的不一致主要是由于方法学上的局限性。未来的研究应该投资于更长的干预期和炎症标志物面板的标准化，同时结合新技术，确保监测人体测量指标并充分使用对照。
PROSPERO 注册号 CRD42017067765。
