Foa R, Catovsky D, Brozovic M, Marsh G, Ooyirilangkumaran T, Cherchi M, Galton D A
Cancer. 1979 Aug;44(2):483-7. doi: 10.1002/1097-0142(197908)44:2<483::aid-cncr2820440217>3.0.co;2-z.
Several immunological markers were tested in 52 untreated cases of chronic lymphocyte leukemia (CLL) to see whether their frequency differed according to the clinical stage in Rai's system. The leukemic cells in all cases had B-cell features as shown by monoclonal immunoglobulins on the cell surface (SmIg) and/or a high percentage of mouse RBC (M)-rosettes. Of the two B-cell markers, the M-rosette test was the more consistently positive. The frequency of these markers did not correlate with clinical staging. The percentage of T-lymphocytes, low in all cases, was found to correlate inversely with the lymphocyte counts, which were higher in advanced stages. The absolute number of T-lymphocytes was above normal in most cases, but did not relat to staging. At least one of the serum Ig, most commonly IgA, was decreased in 87% of cases. Low Ig were slightly less common in Stages 0-I than in advanced stages (II-IV). The above features were also examined in two groups of CLL patients: with stable (9) or progressive (16) disease. The only difference observed between the two groups was that surface IgM only was present in 1 of the 9 stable cases as compared to 9 of the 16 progressive ones. Our findings do not support the suggestions that surface IgM is a feature of a benign form of CLL or that the absolute number of T-lymphocytes correlates with prognosis.
在52例未经治疗的慢性淋巴细胞白血病（CLL）患者中检测了几种免疫标志物，以观察其频率是否因Rai分期系统中的临床分期而异。所有病例中的白血病细胞均具有B细胞特征，表现为细胞表面的单克隆免疫球蛋白（SmIg）和/或高比例的小鼠红细胞（M）玫瑰花结。在这两种B细胞标志物中，M玫瑰花结试验的阳性结果更一致。这些标志物的频率与临床分期无关。所有病例中T淋巴细胞百分比均较低，且发现其与淋巴细胞计数呈负相关，而淋巴细胞计数在晚期更高。大多数病例中T淋巴细胞的绝对数量高于正常，但与分期无关。87%的病例中至少有一种血清免疫球蛋白降低，最常见的是IgA。0-I期低免疫球蛋白的情况比晚期（II-IV期）略少。还对两组CLL患者进行了上述特征检查：疾病稳定组（9例）和疾病进展组（16例）。两组之间观察到的唯一差异是，9例稳定病例中有1例仅存在表面IgM，而16例进展病例中有9例存在。我们的研究结果不支持表面IgM是CLL良性形式的特征或T淋巴细胞绝对数量与预后相关的观点。
