Facile synthesis of metal-organic framework-derived SiW@CoO and its peroxidase-like activity in colorimetric assay.

Over the past few years, artificial enzymes have attracted enormous attention due to their high stabilities and cost-effective productions. In this work, metal-organic framework-derived SiW@CoO was synthesized in large quantities by stirring the mixture at ambient temperature and calcination. The obtained SiW@CoO exhibited a highly inherent peroxidase-like activity and excellent stability. Kinetic studies demonstrated that the synthesized SiW@CoO had a strong binding affinity to 3,3',5,5'-tetramethylbenzidine (TMB), stronger than HRP had. Specifically, the peroxidase-like activity of SiW@CoO in an aqueous solution was well maintained after incubation at an elevated temperature, at an extreme pH and for a long time. A SiW@CoO-based method was further developed for HO and one-pot glucose detection with good sensitivity and reliability. The facile synthesis approach is expected to facilitate the practical use of metal-organic frameworks and their derivatives as enzyme mimics in the future.