Fallahzadeh Hossein, Zareei Mahmood Abadi Hasan, Momayyezi Mahdieh, Malaki Moghadam Hakimeh, Keyghobadi Naeimeh
Research Center of Prevention and Epidemiology of Non-Communicable Disease, School of Public health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Psychology, Faculty of Humanities, Yazd University, Yazd, Iran.
Int J Reprod Biomed. 2019 May 5;17(3):153-62. doi: 10.18502/ijrm.v17i3.4514. eCollection 2019 Mar.
Depression and anxiety are the most common reaction in infertile couples. Several studies have been conducted to examine the psychiatric disorders among infertile and fertile couples.
This meta-analysis was conducted to compare the depression and anxiety in fertile and infertile couples in various studies.
The authors searched articles published in multiple databases including World Health Organization, PubMed, Cochrane Library, Scopus, Science Direct, Medline EMBASE and Persian databases including Scientific Information Database (SID) and IranMedx between 2005 and 2017. The main keywords used for searching the databases were: depression, anxiety, infertility, and fertility. Statistical analyses were performed using Comprehensive Meta-Analysis/2.0 software.
The authors found 42 related articles after searching the databases. 11 articles entered the meta-analysis after considering the inclusion and exclusion criteria. Finally, eight articles were chosen for the comparison of depression and anxiety, two published articles for the comparison of depression, and one published article to compare anxiety in fertile and infertile couples. The results of the heterogeneity test showed a significant heterogeneity among all articles that were analyzed in this meta-analysis in the field of depression and anxiety. The results showed that depression (p = 0.0001; Hedges'g = 1.21; 95% CI 0.63-1.78) and anxiety (p = 0.00001; Hedges'g = 0.63; 95% CI 0.54-0.73) were higher in infertile couples than fertile couples and that the possibility of a publication bias does not exist in this study.
The analysis of articles used in this meta-analysis showed that depression and anxiety scores in infertile couples were higher than fertile couples.
抑郁和焦虑是不孕夫妇最常见的反应。已经开展了多项研究来调查不孕和可育夫妇中的精神障碍情况。
进行这项荟萃分析以比较不同研究中可育和不孕夫妇的抑郁与焦虑情况。
作者检索了多个数据库中2005年至2017年间发表的文章，这些数据库包括世界卫生组织、PubMed、Cochrane图书馆、Scopus、Science Direct、Medline、EMBASE以及波斯语数据库，如科学信息数据库（SID）和伊朗医学数据库（IranMedx）。用于检索数据库的主要关键词为：抑郁、焦虑、不孕和可育。使用综合荟萃分析/2.0软件进行统计分析。
作者在检索数据库后找到42篇相关文章。在考虑纳入和排除标准后，11篇文章进入荟萃分析。最后，选择8篇文章用于比较抑郁和焦虑，2篇已发表文章用于比较抑郁，1篇已发表文章用于比较可育和不孕夫妇的焦虑情况。异质性检验结果显示，在这项荟萃分析中分析的所有文章在抑郁和焦虑领域存在显著异质性。结果表明，不孕夫妇的抑郁（p = 0.0001；Hedges'g = 1.21；95%CI 0.63 - 1.78）和焦虑（p = 0.00001；Hedges'g = 0.63；95%CI 0.54 - 0.73）水平高于可育夫妇，且本研究不存在发表偏倚的可能性。
这项荟萃分析中所使用文章的分析表明，不孕夫妇的抑郁和焦虑得分高于可育夫妇。
