Huang S C, Miki K, Sano J, Ichinose M, Kawamura N, Oka H, Hirano K, Furihata C, Masugi Y, Takahashi K
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
Jpn J Cancer Res. 1988 Oct;79(10):1139-46. doi: 10.1111/j.1349-7006.1988.tb01537.x.
Monoclonal antibodies were used to examine the immunohistochemical expression of pepsinogens I and II in 31 early and 76 advanced gastric cancers. Of the 107 carcinomas studied, 19 contained pepsinogen II and only 3, found exclusively in pepsinogen II-positive cases, contained pepsinogen I. Gastric cancer produces pepsinogen II more frequently than pepsinogen I, and production of the latter is significantly associated with the former. Histologically, there were 54 intestinal-type and 53 diffuse-type cancers. The former produced pepsinogen II more frequently than the latter. In the diffuse type, the four pepsinogen II-positive cases were found exclusively in females. Although the pepsinogen expression was independent of the macroscopic features in advanced gastric cancer, it was found that the protruded-type early gastric cancer produced pepsinogen II more frequently than the depressed type. Incidences of pepsinogen positivity were not different between early and advanced gastric cancers or between cancers with or without lymph node metastasis, suggesting that production of pepsinogen is independent of tumor growth.
采用单克隆抗体检测了31例早期胃癌和76例进展期胃癌中胃蛋白酶原I和II的免疫组化表达。在研究的107例癌组织中，19例含有胃蛋白酶原II，仅3例含有胃蛋白酶原I，且这3例仅在胃蛋白酶原II阳性病例中发现。胃癌产生胃蛋白酶原II的频率高于胃蛋白酶原I，且后者的产生与前者显著相关。组织学上，有54例肠型癌和53例弥漫型癌。前者产生胃蛋白酶原II的频率高于后者。在弥漫型中，4例胃蛋白酶原II阳性病例仅见于女性。尽管胃蛋白酶原表达与进展期胃癌的大体形态特征无关，但发现隆起型早期胃癌产生胃蛋白酶原II的频率高于凹陷型。早期胃癌和进展期胃癌之间，以及有或无淋巴结转移的癌之间，胃蛋白酶原阳性率无差异，提示胃蛋白酶原的产生与肿瘤生长无关。
