Jisha Ninan, Vysakh A, Vijeesh V, Latha M S
School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.
School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.
Pathophysiology. 2019 Sep-Dec;26(3-4):323-330. doi: 10.1016/j.pathophys.2019.08.002. Epub 2019 Aug 10.
The plant Muntingia calabura L. is a well-known herb which gained attention due to its pharmacological value. The necessity of this plant in human ailments is illustrious in old medical practices. Muntingia calabura L. leaves were therapeutically used for ulcer, fever, headache etc. The study was designed to assess the acute toxicity and anti-inflammatory potential of methanolic extract of Muntingia calabura L. (MEMC) in in vivo models. Two different doses (550, 2000 mg/kg body weight) of MEMC were taken to evaluate the acute toxicity response. The drugs were given orally to wistar rats and were monitored for behavioral changes and mortality for 14 days period. The blood parameter analysis, serum analysis of liver and kidney injury markers and histopathological evaluation of kidney, heart and liver were carried out. The Carrageenan induced paw edema model was performed to inspect the anti-inflammatory response of MEMC. The level of CRP in serum and the histological alterations in the paw tissue were evaluated. There were no evident symptoms of toxicity observed in animals treated with MEMC at the dose of 2000 mg/kg body weight. The Carrageenan induced paw edema model study established the anti-inflammatory potential of MEMC. The MEMC, which is innoxious, can act as a potential anti-inflammatory drug.
假苹婆是一种著名的草药，因其药理价值而受到关注。在传统医学实践中，这种植物对人类疾病的必要性是显而易见的。假苹婆叶在治疗上可用于治疗溃疡、发烧、头痛等。本研究旨在评估假苹婆甲醇提取物（MEMC）在体内模型中的急性毒性和抗炎潜力。采用两种不同剂量（550、2000mg/kg体重）的MEMC来评估急性毒性反应。将药物口服给予Wistar大鼠，并在14天内监测其行为变化和死亡率。进行了血液参数分析、肝肾功能损伤标志物的血清分析以及肾脏、心脏和肝脏的组织病理学评估。采用角叉菜胶诱导的爪肿胀模型来检测MEMC的抗炎反应。评估了血清中CRP水平和爪组织的组织学改变。在体重为2000mg/kg剂量的MEMC处理的动物中未观察到明显的毒性症状。角叉菜胶诱导的爪肿胀模型研究证实了MEMC的抗炎潜力。无毒的MEMC可作为一种潜在的抗炎药物。
