Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Radiology, Virginia Commonwealth University, Richmond, VA, USA.
Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Psychiatry Res Neuroimaging. 2019 Dec 30;294:110977. doi: 10.1016/j.pscychresns.2019.08.005. Epub 2019 Aug 13.
Individuals with opioid use disorder (OUD) often relapse when exposed to opioid-related cues. Previous functional magnetic resonance imaging (fMRI) studies have identified neuronal corticolimbic changes related to drug cue reactivity in OUD. However, the corresponding manner in which brain regions interact is still unclear. Effective (directional) connectivity was analyzed using dynamic causal modeling of fMRI data acquired from 27 OUD participants (13 with OUD and 14 with OUD and cocaine use disorder [OUD+CUD]), while performing an opioid-word Stroop task. Participants were shown opioid and neutral words presented in different colors and were instructed to indicate word color but ignore word meaning. The effects of opioid words relative to neutral words on effective connectivity and on behavioral reaction time were defined as modulatory change and attentional bias, respectively. For all the 27 participants, left anterior cingulate cortex (ACC) to right hippocampus effective connectivity exhibited the largest modulatory change, which was positively correlated with attentional bias. The findings for the ACC to hippocampus EC were consistent across OUD and CUD found in a previous study.
患有阿片类药物使用障碍（OUD）的个体在接触阿片类相关线索时经常会复发。先前的功能磁共振成像（fMRI）研究已经确定了与 OUD 药物线索反应相关的神经元皮质边缘变化。然而，大脑区域相互作用的相应方式仍不清楚。对 27 名 OUD 参与者（13 名 OUD 患者和 14 名 OUD 和可卡因使用障碍[OUD+CUD]患者）在执行阿片类药物字词 Stroop 任务时采集的 fMRI 数据进行了动态因果建模，以分析有效（定向）连通性。参与者被呈现不同颜色的阿片类和中性词，并被指示指示单词颜色但忽略单词含义。与中性词相比，阿片类词对有效连接和行为反应时间的影响分别定义为调节变化和注意力偏差。对于所有 27 名参与者，左前扣带皮层（ACC）到右海马体的有效连接显示出最大的调节变化，与注意力偏差呈正相关。在以前的一项研究中，对 OUD 和 CUD 的发现表明，ACC 到海马体 EC 的发现是一致的。
