Li Yan, Lu Gengxi, Chen Jason J, Jing Joseph C, Huo Tiancheng, Chen Ruimin, Jiang Laiming, Zhou Qifa, Chen Zhongping
Beckman Laser Institute, University of California, Irvine, Irvine, CA 92617, USA.
Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.
Photoacoustics. 2019 Jun 20;15:100138. doi: 10.1016/j.pacs.2019.100138. eCollection 2019 Sep.
Endoscopic dual-modality photoacoustic (PA) and ultrasound (US) imaging has the capability of providing morphology and molecular information simultaneously. An ultrasonic transducer was applied for detecting PA signals and performing US imaging which determines the sensitivity and performance of a dual-modality PA/US system. In our study, a miniature single element 32-MHz lead magnesium niobate-lead titanate (PMN-PT) epoxy 1-3 composite based ultrasonic transducer was developed. A miniature endoscopic probe based on this transducer has been fabricated. Using the dual modality PA/US system with a PMN-PT/epoxy 1-3 composite based ultrasonic transducer, phantom and animal studies have been conducted to evaluate the performance. The preliminary results show enhanced bandwidths of the new ultrasonic transducer and improved signal-to-noise ratio of PA and US images of rat colorectal wall compared with PMN-PT and lead zirconate titanate (PZT) composite based ultrasonic transducers.
内镜双模态光声（PA）和超声（US）成像能够同时提供形态学和分子信息。应用超声换能器检测光声信号并进行超声成像，这决定了双模态光声/超声系统的灵敏度和性能。在我们的研究中，开发了一种基于微型单元素32兆赫铌镁酸铅-钛酸铅（PMN-PT）环氧树脂1-3复合材料的超声换能器。基于该换能器制造了一种微型内镜探头。使用基于PMN-PT/环氧树脂1-3复合材料超声换能器的双模态光声/超声系统，进行了体模和动物研究以评估其性能。初步结果表明，与基于PMN-PT和锆钛酸铅（PZT）复合材料的超声换能器相比，新型超声换能器的带宽有所增加，大鼠结直肠壁光声和超声图像的信噪比有所提高。
