Li Tianwen, Zhu Jianhong
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
State Key Laboratory of Medical Neurobiology, Shanghai, China.
Front Aging Neurosci. 2019 Aug 7;11:209. doi: 10.3389/fnagi.2019.00209. eCollection 2019.
Although the mechanisms of Alzheimer's disease are diverse and unclear, the past 20 years have witnessed the unprecedented development of the AD inflammation theory. As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable participant in the cause of Alzheimer's disease; of this family, CCR5 is the most widely studied. CCR5 is an essential entrance when HIV infects immune cells and is also involved in other inflammatory and immune activities. New evidence on the inevitably intertwined link between Alzheimer's disease and CCR5 indicates that CCR5 accelerates the development of Alzheimer's disease, and few studies disputed it. The role of CCR5 in Alzheimer's disease remains elusive. However, as the research progresses, this intricate relationship will gradually be uncovered.
尽管阿尔茨海默病的发病机制多样且尚不明确，但在过去20年里，阿尔茨海默病炎症理论取得了前所未有的发展。作为关键的炎症受体家族，C-C趋化因子受体家族在阿尔茨海默病病因中是一个显著的参与者；在这个家族中，CCR5是研究最广泛的。CCR5是HIV感染免疫细胞时的一个重要入口，也参与其他炎症和免疫活动。关于阿尔茨海默病与CCR5之间不可避免地交织在一起的联系的新证据表明，CCR5加速了阿尔茨海默病的发展，很少有研究对此提出异议。CCR5在阿尔茨海默病中的作用仍然难以捉摸。然而，随着研究的进展，这种复杂的关系将逐渐被揭示出来。
