Luo Junqiu, Chen Daiwen, Mao Xiangbing, He Jun, Yu Bing, Cheng Long, Zeng Dafu
Institute of Animal Nutrition, Sichuan Agricultural University, and Key Laboratory of Animal Disease Resistance Nutrition Ministry of Education, Chengdu 611130, Sichuan, China.
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Dookie Campus, VIC 3647, Australia.
Animals (Basel). 2019 Aug 24;9(9):602. doi: 10.3390/ani9090602.
This study investigated β-glucan derived from sp. ZX09 with high (2000 kDa) and low (300 kDa) molecular weight (MW) to compare their effects on growth performance and gut function in LPS-induced weaned piglets. Changes in jejunal morphology, mucosal barrier function, microbial populations, and fermentation in the piglets were determined. Data showed that β-glucan prevented body weight loss in LPS challenged piglets. Supplementation with both β-glucan fractions improved jejunal morphology. Compared to low MW, β-glucan of high MW generally up-regulated transcripts of , , and and concentration of butyrate emerged after feeding β-glucan with high MW. Results suggested that the effect of sp. ZX09 β-glucans on the gut-modulatory function is largely linked to their MW. Low MW β-glucan mainly improved the mucosal barrier function in the jejunum, while high MW β-glucan had profound effects on the microbial community and fermentation in the hindgut of piglets.
本研究调查了来源于ZX09菌株的高（2000 kDa）、低（300 kDa）分子量（MW）的β-葡聚糖，以比较它们对脂多糖诱导的断奶仔猪生长性能和肠道功能的影响。测定了仔猪空肠形态、黏膜屏障功能、微生物种群和发酵的变化。数据表明，β-葡聚糖可防止脂多糖攻击的仔猪体重减轻。补充两种β-葡聚糖组分均可改善空肠形态。与低分子量β-葡聚糖相比，高分子量β-葡聚糖通常上调了某些基因的转录本，且在饲喂高分子量β-葡聚糖后出现丁酸盐浓度升高。结果表明，ZX09菌株β-葡聚糖对肠道调节功能的影响很大程度上与其分子量有关。低分子量β-葡聚糖主要改善空肠黏膜屏障功能，而高分子量β-葡聚糖对仔猪后肠微生物群落和发酵有深远影响。
