Green Templeton College, University of Oxford, Oxford, UK.
University College Hospital, London, UK.
J Cosmet Dermatol. 2024 May;23(5):1551-1559. doi: 10.1111/jocd.16185. Epub 2024 Jan 29.
Androgenetic alopecia (AGA), also referred to as male or female pattern hair loss, is the commonest cause of chronic hair loss and affects up to 80% of men by the age of 70. Despite a high prevalence, there are few approved therapies, which show minimal efficacy.
This systematic review aims to evaluate the efficacy of platelet-rich plasma (PrP) in the treatment of AGA in male patients.
MEDLINE, EMBASE, Cochrane (CENTRAL), CINAHL, clinicaltrials.gov, Google Scholar and the Science Citation Index database were searched to identify eligible studies. All randomized controlled trials (RCTs) and prospective cohort studies related to PrP use in AGA were included. Primary outcomes included changes in hair density and hair count. Methodological quality was assessed using bias assessment tools.
Eight RCTs and one cohort study were included in the review with a total of 291 participants. Six studies reported a statistically significant increase in hair density in the PrP group versus the control. Five studies reported a statistically significant increase in hair count with PrP. Seven studies showed moderate risk and two showed low risk of bias.
In a methodologically robust review on the effectiveness of PrP on male AGA, PrP demonstrated some potential to be used therapeutically. However, the low quality of evidence, moderate risk of bias, and high heterogeneity of included studies limit inferences and call for more robust designs to investigate this further.
雄激素性脱发（AGA），也称为男性型或女性型脱发，是最常见的慢性脱发原因，高达 80%的男性在 70 岁时会受到影响。尽管患病率很高，但批准的治疗方法很少，且疗效甚微。
本系统评价旨在评估富血小板血浆（PrP）治疗男性 AGA 的疗效。
检索 MEDLINE、EMBASE、Cochrane（CENTRAL）、CINAHL、clinicaltrials.gov、Google Scholar 和科学引文索引数据库，以确定合格的研究。纳入所有与 PrP 在 AGA 中的使用相关的随机对照试验（RCT）和前瞻性队列研究。主要结局包括头发密度和头发计数的变化。使用偏倚评估工具评估方法学质量。
共纳入 8 项 RCT 和 1 项队列研究，总计 291 名参与者。6 项研究报告 PrP 组的头发密度有统计学意义的增加。5 项研究报告 PrP 治疗后头发计数有统计学意义的增加。7 项研究显示中度偏倚风险，2 项研究显示低偏倚风险。
在一项关于 PrP 治疗男性 AGA 有效性的方法学稳健的综述中，PrP 显示出具有一定的治疗潜力。然而，证据质量低、偏倚风险中度以及纳入研究的高度异质性限制了推断，并呼吁进行更稳健的设计来进一步研究这一问题。
