O'Connor Sarah, Julien Pierre, Weisnagel Stanley John, Gagnon Claudia, Rudkowska Iwona
Endocrinology and Nephrology Unit, Centre hospitalier universitaire de Québec-Laval University Research Center, Québec, Quebec, Canada.
Department of Kinesiology, Laval University, Québec, Quebec, Canada.
Curr Dev Nutr. 2019 Jul 24;3(8):nzz083. doi: 10.1093/cdn/nzz083. eCollection 2019 Aug.
Dairy product intake has been associated with decreased risk of type 2 diabetes (T2D) in cohort studies. However, results from clinical trials on T2D-related risk factors remain inconclusive.
The aim of this clinical trial was to evaluate the impact of high dairy product intake (HD) (≥4 servings/d) for 6 wk, compared with an adequate dairy product intake (AD) (≤2 servings/d), on glycemic and insulinemic parameters, insulin sensitivity, insulin secretion, and β-cell function in hyperinsulinemic adults.
In this crossover clinical trial, hyperinsulinemic adults were randomly assigned to HD or AD for 6 wk, then crossed over after a 6-wk washout period. Serum glucose, insulin, C-peptide, HOMA-IR, Matsuda index, insulinogenic index, and disposition index were measured and analyzed using a repeated-measures mixed model adjusted for age, sex, and BMI. Anthropometric measures were collected and food intake was evaluated using a validated FFQ.
Nineteen men and 8 women completed the study (mean ± SD age: 55 ± 14 y; BMI: 31.3 ± 3.3 kg/m. Dairy product intake was 5.8 servings/d in the HD condition and 2.3 servings/d in the AD condition after 6 wk. No difference was observed between HD and AD after 6 wk for all outcomes.
HD does not affect glycemic and insulinemic parameters, insulin sensitivity, insulin secretion, and β-cell function over AD in hyperinsulinemic adults. Additional larger and longer studies assessing T2D-related risk factors are required. This trial was registered at clinicaltrials.gov as NCT02961179.
队列研究表明，摄入乳制品与2型糖尿病（T2D）风险降低有关。然而，关于T2D相关危险因素的临床试验结果尚无定论。
本临床试验旨在评估高乳制品摄入量（HD）（≥4份/天）持续6周与适量乳制品摄入量（AD）（≤2份/天）相比，对高胰岛素血症成年人的血糖和胰岛素参数、胰岛素敏感性、胰岛素分泌及β细胞功能的影响。
在这项交叉临床试验中，高胰岛素血症成年人被随机分配至HD组或AD组，为期6周，然后在6周的洗脱期后进行交叉。使用针对年龄、性别和BMI调整的重复测量混合模型测量并分析血清葡萄糖、胰岛素、C肽、HOMA-IR、松田指数、胰岛素生成指数和处置指数。收集人体测量数据，并使用经过验证的食物频率问卷评估食物摄入量。
19名男性和8名女性完成了研究（平均±标准差年龄：55±14岁；BMI：31.3±3.3kg/m²）。6周后，HD组的乳制品摄入量为5.8份/天，AD组为2.3份/天。6周后，HD组和AD组在所有结局方面均未观察到差异。
在高胰岛素血症成年人中，与AD相比，HD对血糖和胰岛素参数、胰岛素敏感性、胰岛素分泌及β细胞功能无影响。需要开展更多规模更大、时间更长的评估T2D相关危险因素的研究。本试验已在clinicaltrials.gov上注册，注册号为NCT02961179。
