Research Division, Institute of Mental Health (IMH), Buangkok Green Medical Park, 10 Buangkok View, Singapore, 539747, Singapore.
Ministry of Health (MOH), Singapore, Singapore.
Soc Psychiatry Psychiatr Epidemiol. 2020 Jan;55(1):33-43. doi: 10.1007/s00127-019-01755-1. Epub 2019 Aug 27.
Migraine is a highly prevalent and disabling neurological disorder associated with a wide range of psychiatric comorbidities. Studies have revealed that those with migraine headache and coexisting psychiatric disorders have poorer treatment outcomes and increased disability. The study aims to establish the prevalence, correlates, and comorbidities of migraine headache among the multi-ethnic Asian population in Singapore.
Data were extracted from the Singapore Mental Health Study 2016 (SMHS 2016), a cross-sectional epidemiological survey of a nationally representative sample. Face-to-face interviews were completed with 6126 participants between 2016 and 2017. The data relating to chronic medical conditions, psychiatric conditions, and 30-day functioning and disability were captured using the World Mental Health Composite International Diagnostic Interview (CIDI) version 3.0.
The lifetime prevalence for migraine headache in the Singapore general population was 8.2%. Malay ethnicity (versus Chinese), female gender (versus male), and diploma holders (versus university) were significantly more likely to experience migraine headache. Participants belonging to the older age group (65 years and above versus 18-34 years of age), and those who were economically inactive (versus employed) were less likely to experience migraine headache. The mean age of onset for migraine was 26.4 years (SD = 11.1). Poisson regression analyses showed that migraine headache was also significantly associated with psychiatric conditions such as major depressive disorder (MDD) (prevalence ratio (PR), 1.80; 95% CI, 1.25-2.58), bipolar disorder (BD) (PR, 3.55; 95% CI, 2.29-5.51), generalized anxiety disorder (GAD) (PR, 2.04; 95% CI, 1.12-3.69), obsessive compulsive disorder (OCD) (PR, 2.20; 95% CI, 1.49-3.26), and alcohol use disorder (AUD) (PR, 1.93; 95% CI, 1.20-3.08). Those with migraine headache were significantly associated with poor functioning and disability compared to those without migraine headache.
Our study showed significant associations between migraine headache and psychiatric disorders, as well as with role functioning and disability. The findings of our study emphasise the need for screening for psychiatric comorbidity among those with migraine and the development of appropriate interventions for this group.
偏头痛是一种高发且致残的神经系统疾病，与广泛的精神共病有关。研究表明，偏头痛头痛伴发精神障碍的患者治疗效果较差，残疾程度更高。本研究旨在确定新加坡多民族亚洲人群中偏头痛头痛的患病率、相关因素和共病情况。
数据来自 2016 年新加坡精神健康研究（SMHS 2016），这是一项针对全国代表性样本的横断面流行病学调查。2016 年至 2017 年期间，对 6126 名参与者进行了面对面访谈。使用世界精神卫生复合国际诊断访谈（CIDI）第 3.0 版记录与慢性疾病、精神疾病以及 30 天功能和残疾相关的数据。
新加坡普通人群偏头痛头痛的终生患病率为 8.2%。马来族（相对于华族）、女性（相对于男性）和持有文凭的人（相对于大学学历）更有可能经历偏头痛头痛。属于较年长年龄组（65 岁及以上相对于 18-34 岁）和经济上不活跃的人（相对于就业）偏头痛头痛的可能性较小。偏头痛头痛的平均发病年龄为 26.4 岁（SD=11.1）。泊松回归分析显示，偏头痛头痛还与精神疾病显著相关，如重度抑郁症（MDD）（患病率比（PR），1.80；95%可信区间，1.25-2.58）、双相情感障碍（BD）（PR，3.55；95%可信区间，2.29-5.51）、广泛性焦虑障碍（GAD）（PR，2.04；95%可信区间，1.12-3.69）、强迫症（OCD）（PR，2.20；95%可信区间，1.49-3.26）和酒精使用障碍（AUD）（PR，1.93；95%可信区间，1.20-3.08）。与没有偏头痛头痛的人相比，患有偏头痛头痛的人在功能和残疾方面明显较差。
我们的研究表明，偏头痛头痛与精神障碍以及角色功能和残疾之间存在显著关联。我们研究的结果强调了对偏头痛患者进行精神共病筛查的必要性，并为这一人群制定适当的干预措施。
