Dong Lingkang, Dong Wenqi, Jin Yuchen, Jiang Yumeng, Li Zhuangzhuang, Yu Dongzhen
Department of Otolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Pain Ther. 2025 Feb;14(1):297-315. doi: 10.1007/s40122-024-00690-7. Epub 2024 Dec 11.
Migraine is a prevalent neurological disorder causing significant disability worldwide. Despite extensive research on specific populations, comprehensive analyses of global trends are remains limited.
We extracted incidence, prevalence, and disability-adjusted life years (DALYs) data for migraine from the Global Burden of Disease 2021 database. Trends were analyzed across regions, age groups, sexes, and sociodemographic index (SDI) using estimated annual percentage changes (EAPC). Predictive models (ARIMA) were used to forecast trends to 2050.
From 1990 to 2021, the global burden of migraine significantly increased: prevalence increased by 58.15%, from 732.56 million to 1.16 billion cases, and incidence increased by 42.06%. The DALYs also increased by 58.27%. There were differences between the sexes: female individuals had higher absolute rates of migraine incidence and prevalence, but male individuals exhibited a four- to five-fold more rapid increase than female individuals in these parameters. Adolescents (< 20 years old) have the fastest growth in prevalence and DALYs. Regionally, high SDI regions having the highest age-standardized rate (ASR) and low SDI regions having the lowest ASR in DALYs. East Asia and Latin America exhibited the most significant increases in migraine burden, whereas Southeast Asia exhibited the most pronounced decrease. Predictive analysis suggests prevalence will continue to rise until 2050, particularly among male individuals and adolescents.
The global burden of migraine has significantly escalated from 1990 to 2021, with female individuals bearing a greater burden but male individuals showing a faster growth rate. Adolescents also face a rapidly rising prevalence. Disparities across SDI regions, countries, age groups, and sexes emphasize the need for targeted public health strategies. Focused interventions are required to mitigate the growing impact of migraines on global health, particularly among male individuals and adolescents.
偏头痛是一种常见的神经系统疾病，在全球范围内导致严重的残疾。尽管对特定人群进行了广泛研究，但对全球趋势的全面分析仍然有限。
我们从《2021年全球疾病负担》数据库中提取了偏头痛的发病率、患病率和伤残调整生命年（DALYs）数据。使用估计年百分比变化（EAPC）分析了各地区、年龄组、性别和社会人口指数（SDI）的趋势。采用预测模型（ARIMA）预测到2050年的趋势。
从1990年到2021年，全球偏头痛负担显著增加：患病率增加了58.15%，从7.3256亿例增至11.6亿例，发病率增加了42.06%。伤残调整生命年也增加了58.27%。性别之间存在差异：女性偏头痛发病率和患病率的绝对比率较高，但男性在这些参数上的增长速度比女性快四至五倍。青少年（<20岁）的患病率和伤残调整生命年增长最快。在地区方面，高社会人口指数地区的年龄标准化率（ASR）最高，低社会人口指数地区的伤残调整生命年年龄标准化率最低。东亚和拉丁美洲的偏头痛负担增加最为显著，而东南亚则下降最为明显。预测分析表明，到2050年患病率将持续上升，尤其是在男性和青少年中。
从1990年到2021年，全球偏头痛负担显著加剧，女性负担更大，但男性增长速度更快。青少年的患病率也在迅速上升。社会人口指数地区、国家、年龄组和性别之间的差异凸显了制定有针对性的公共卫生策略的必要性。需要采取有针对性的干预措施来减轻偏头痛对全球健康日益增加的影响，特别是在男性和青少年中。
