State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022, P. R. China.
University of Science and Technology of China, Hefei, Anhui, 230029, P. R. China.
Angew Chem Int Ed Engl. 2019 Nov 4;58(45):16236-16242. doi: 10.1002/anie.201908289. Epub 2019 Sep 26.
Nanozymes have emerged as a new generation of antibiotics with exciting broad-spectrum antimicrobial properties and negligible biotoxicities. However, their antibacterial efficacies are unsatisfactory due to their inability to trap bacteria and their low catalytic activity. Herein, we report nanozymes with rough surfaces and defect-rich active edges. The rough surface increases bacterial adhesion and the defect-rich edges exhibit higher intrinsic peroxidase-like activity compared to pristine nanozymes due to their lower adsorption energies of H O and desorption energy of OH*, as well as the larger exothermic process for the whole reaction. This was demonstrated using drug-resistant Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus in vitro and in vivo. This strategy can be used to engineer nanozymes with enhanced antibacterial function and will pave a new way for the development of alternative antibiotics.
纳米酶作为新一代抗生素，具有令人兴奋的广谱抗菌特性和可忽略不计的生物毒性。然而，由于它们无法捕获细菌和催化活性低，其抗菌效果并不令人满意。在此，我们报告了具有粗糙表面和富含缺陷活性边缘的纳米酶。粗糙的表面增加了细菌的黏附性，而富含缺陷的边缘由于其对 H2O 的吸附能和 OH*的解吸能较低，以及整个反应的放热过程较大，表现出比原始纳米酶更高的固有过氧化物酶样活性。这在体外和体内使用耐抗生素的革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌进行了验证。该策略可用于工程化具有增强抗菌功能的纳米酶，并为替代抗生素的开发开辟新途径。
