Christine Tamara, Tarigan Amira Permatasari, Ananda Fannie Rizki
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Sumatera Utara (USU), Adam Malik General Hospital, Medan, Indonesia.
Open Access Maced J Med Sci. 2019 Jul 13;7(13):2075-2078. doi: 10.3889/oamjms.2019.544. eCollection 2019 Jul 15.
Untreated or undertreated, pulmonary tuberculosis could cause severe complications until death. After treatment, residual lesions might occur. The presence of residual lesions is varied, including fibrosis, cavity, bronchiectasis and calcification. Transforming growth factor-β (TGF-β) is a cytokine associated with lung inflammation, which plays a role in lung fibrosis. However, only a few studies have assessed the serum level of TGF-β in post-treatment tuberculosis patients.
The main objective of this study was to determine the correlation between TGF-β levels and pulmonary fibrosis in patients with pulmonary tuberculosis.
A group of 51 patients that had undergone anti-tuberculosis treatment were observed, consisting of 31 men, 20 women. Of all patients, there were 26 people with a smoking history, including 25 men and 1 woman. All patients had been recovered, confirmed by the clinical state, laboratory and radiology examination. The ELISA test was performed to measure TGF-β level, while the chest X-ray was used to look for the occurrence of pulmonary fibrosis.
The mean level of TGF-β in patients with a lesion (+) was 7628.02 (SD: ± 4928.38) while the mean level of TGF-β in patients with a lesion (-) was 2315.11 (SD: ± 505.83). The statistical test showed a significant relationship between TGF-β level and fibrosis lesion (p < 0.001).
TGF-β level was significantly higher in post-tuberculosis patients with pulmonary fibrosis.
未经治疗或治疗不充分的肺结核可能导致严重并发症直至死亡。治疗后，可能会出现残留病灶。残留病灶的表现各异，包括纤维化、空洞、支气管扩张和钙化。转化生长因子-β（TGF-β）是一种与肺部炎症相关的细胞因子，在肺纤维化中起作用。然而，仅有少数研究评估了肺结核治疗后患者血清中TGF-β的水平。
本研究的主要目的是确定肺结核患者中TGF-β水平与肺纤维化之间的相关性。
观察一组51例接受抗结核治疗的患者，其中男性31例，女性20例。所有患者中，有26人有吸烟史，包括25名男性和1名女性。所有患者经临床状态、实验室及影像学检查证实已康复。采用酶联免疫吸附测定（ELISA）试验检测TGF-β水平，同时通过胸部X线检查观察肺纤维化的发生情况。
病灶（+）患者的TGF-β平均水平为7628.02（标准差：±4928.38），而病灶（-）患者的TGF-β平均水平为2315.11（标准差：±505.83）。统计学检验显示TGF-β水平与纤维化病灶之间存在显著相关性（p<0.001）。
肺结核后发生肺纤维化的患者TGF-β水平显著更高。
