Gupta Ajay, Jamatia Ramen, Patil Ranjit A, Ma Yuan-Ron, Pal Amarta Kumar
Department of Chemistry, Centre for Advanced Studies, North-Eastern Hill University, NEHU campus, Shillong 793022, India.
Department of Physics, National Dong Hwa University, Hualien 97401, Taiwan.
ACS Omega. 2018 Jul 3;3(7):7288-7299. doi: 10.1021/acsomega.8b00334. eCollection 2018 Jul 31.
An efficient, green, and sustainable synthesis of new hybrid molecules containing flavanone with triazole by merging the Michael addition and Click reaction using a copper oxide/reduced graphene oxide nanocomposite in one pot is reported. The catalyst can easily be recycled and reused in seven consecutive runs without compromising the product yields. Other notable advantages include using water as a reaction medium and obtaining good to excellent yields, low catalyst loading, high atom efficiency, high substrate variation, and good results in the gram scale reaction.
报道了一种通过在一锅法中使用氧化铜/还原氧化石墨烯纳米复合材料合并迈克尔加成反应和点击反应，高效、绿色且可持续地合成含黄酮酮和三唑的新型杂化分子的方法。该催化剂可轻松回收并连续七次重复使用而不影响产物收率。其他显著优点包括使用水作为反应介质，获得良好至优异的收率、低催化剂负载量、高原子效率、高底物多样性以及在克级反应中取得良好结果。
