生物膜形成微生物的干预、治疗及抗生素耐药性挑战
Challenges of intervention, treatment, and antibiotic resistance of biofilm-forming microorganisms.
作者信息
Gebreyohannes Gebreselema, Nyerere Andrew, Bii Christine, Sbhatu Desta Berhe
机构信息
Department of Biological and Chemical Engineering, Mekelle Institute of Technology, Mekelle University, Ethiopia.
Molecular Biology and Biotechnology, Pan African University, Institute for Basic Sciences, Technology, and Innovation, Nairobi, Kenya.
出版信息
Heliyon. 2019 Aug 19;5(8):e02192. doi: 10.1016/j.heliyon.2019.e02192. eCollection 2019 Aug.
BACKGROUND
Biofilms are multicellular communities of microorganisms held together by a self-produced extracellular matrix. The ability of microbes to form biofilm is a universal, ubiquitous, and dynamic process. This dynamic process of biofilms establishes an important strategy to withstand and survive harsh environmental conditions and antimicrobial agents.
OBJECTIVE
This review paper aims to give an overview of antibiotic resistance, intervention, and treatment of infections caused by biofilm-forming organisms. Moreover, it can also help to motivate scholars to search for new anti-biofilm strategies and most appropriate methods to tackle the effect of biofilm infections on healthcare services.
METHODS
This paper was written by reviewing recent research and review articles which are reporting about the antibiotic resistance, prevention, and treatment of biofilm-producing organisms.
CONCLUSION
Bioprospecting for quorum quenching compounds can be an appropriate solution for controlling biofilm infections.
背景
生物膜是由微生物自身产生的细胞外基质维系在一起的多细胞群落。微生物形成生物膜的能力是一个普遍、无处不在且动态的过程。生物膜的这种动态过程确立了一种重要策略，使其能够在恶劣环境条件和抗菌剂作用下存活。
目的
本综述旨在概述由形成生物膜的生物体引起的感染的抗生素耐药性、干预措施及治疗方法。此外，它还有助于激励学者探寻新的抗生物膜策略以及应对生物膜感染对医疗服务影响的最合适方法。
方法
本文通过回顾近期有关产生生物膜的生物体的抗生素耐药性、预防和治疗的研究及综述文章撰写而成。
结论
对群体感应淬灭化合物进行生物勘探可能是控制生物膜感染的合适解决方案。
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