Wu Zhiyou, Duan Fei, Zhang Jinde, Li Shi, Ma Haosong, Nie Liming
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Biomed Opt Express. 2019 Jun 18;10(7):3425-3433. doi: 10.1364/BOE.10.003425. eCollection 2019 Jul 1.
Accurate diagnoses of superficial and deep dermal burns are difficult to make even by experienced investigators due to slight differences in dermis damage. Many imaging technologies have been developed to improve the burn depth assessment. But these imaging tools have limitations in deep imaging or resolving ability. Photoacoustic imaging is a hybrid modality combining optical and ultrasound imaging that remains high resolution in deep imaging depth. In this work, we used dual-scale photoacoustic imaging to noninvasively diagnose burn injury and monitor the burn healing. Real-time PACT provided cross-sectional and volumetric images of the burn region. High-resolution PAM allowed for imaging of angiogenesis on the hyperemic ring. A long-term surveillance was also performed to assess the difference between the two damage degrees of burn injuries. Our proposed method suggests an effective tool to diagnose and monitor burn injury.
即使是经验丰富的研究人员，也很难准确诊断浅表和深部真皮烧伤，因为真皮损伤存在细微差异。为了改进烧伤深度评估，人们开发了许多成像技术。但这些成像工具在深度成像或分辨能力方面存在局限性。光声成像是一种将光学成像和超声成像相结合的混合模式，在深度成像深度上仍保持高分辨率。在这项工作中，我们使用双尺度光声成像来无创诊断烧伤损伤并监测烧伤愈合。实时光声断层成像提供了烧伤区域的横截面和体积图像。高分辨率光声显微镜能够对充血环上的血管生成进行成像。我们还进行了长期监测，以评估两种烧伤损伤程度之间的差异。我们提出的方法为诊断和监测烧伤损伤提供了一种有效的工具。
