Guerra-Tapia A, Buendía-Eisman A, Ferrando Barbera J
Servicio de Dermatología, Hospital Universitario 12 de Octubre; Facultad de Medicina, Universidad Complutense, Madrid, España.
Facultad de Medicina, Universidad de Granada, Granada, España.
Actas Dermosifiliogr (Engl Ed). 2019 Dec;110(10):819-829. doi: 10.1016/j.ad.2019.06.003. Epub 2019 Aug 29.
Work has already been done on validating the cross-cultural adaptation of the Hair-Specific Skindex-29 questionnaire (HSS-29) into Spanish. This questionnaire measures the impact of female-pattern hair loss on health-related quality of life (HRQoL). The aim of this study was to complete the validation process by testing the questionnaire's sensitivity to change and assessing its correlation with the generic 12-item Short-Form Health Survey (SF-12).
Patients who started treatment with a nutritional supplement that blocks the activity of 5-alpha-reductase were seen in two visits: a baseline visit and a follow-up visit at 6months. At each visit, hair loss severity was assessed by both investigators and patients via the Sinclair scale, evaluation of hair condition, and administration of HSS-29 and SF-12.
In total, 983 women with female-pattern hair loss participated in the study. The mean HSS-29 score decreased from 25.7±18.7 at baseline to 19.3±15.7 at follow-up and significant changes were also observed in the functioning, emotions, and symptoms domains. Changes in overall and subscale HSS-29 scores from baseline to follow-up were all significantly correlated with changes in SF-12 subscale scores. The Pearson correlation coefficients ranged from -0.1 to -0.4 and were all significant at P<.001.
The Spanish version of HSS-29 is sensitive to change, as it detected changes in objective measurements of HRQoL. Correlations between HSS-29 and SF-12 scores were also observed.
针对将特定毛发的Skindex-29问卷（HSS-29）跨文化改编为西班牙语的有效性验证工作已经完成。该问卷用于衡量女性型脱发对健康相关生活质量（HRQoL）的影响。本研究的目的是通过测试问卷对变化的敏感性并评估其与通用的12项简短健康调查（SF-12）的相关性来完成验证过程。
开始使用抑制5-α还原酶活性的营养补充剂进行治疗的患者接受了两次就诊：基线就诊和6个月后的随访就诊。每次就诊时，研究人员和患者均通过辛克莱量表、头发状况评估以及HSS-29和SF-12的施测来评估脱发严重程度。
共有983名女性型脱发患者参与了该研究。HSS-29的平均得分从基线时的25.7±18.7降至随访时的19.3±15.7，并且在功能、情绪和症状领域也观察到了显著变化。从基线到随访，HSS-29总分及各子量表得分的变化均与SF-12子量表得分的变化显著相关。Pearson相关系数范围为-0.1至-0.4，均在P<0.001水平上具有显著性。
HSS-29西班牙语版对变化敏感，因为它检测到了HRQoL客观测量中的变化。还观察到了HSS-29与SF-12得分之间的相关性。
