Jensen K E, Thomsen C, Henriksen O
Department of Magnetic Resonance, Hvidovre Hospital, University of Copenhagen, Denmark.
Acta Physiol Scand. 1988 Oct;134(2):295-8. doi: 10.1111/j.1748-1716.1988.tb08492.x.
The effect of changes in carbon dioxide tension in arterial blood upon intracellular pH in brain tissue was studied in seven healthy volunteers, aged 22-45 years. The pH changes were monitored by use of 31P nuclear magnetic resonance spectroscopy, performed on a whole-body 1.5 Tesla Siemens imaging system. The measurements were carried out during hyperventilation and with the subject breathing atmospheric air containing 5 vol. % and 7 vol. % carbon dioxide. Intracellular pH increased significantly during 15 min of hyper-ventilation and decreased significantly during 18 min respiration of air containing 7 vol. % carbon dioxide. The intracellular buffer capacity was estimated. These results suggest that the ventilation response to carbon dioxide is correlated to changes in intracellular fluid pH.
对7名年龄在22至45岁之间的健康志愿者，研究了动脉血中二氧化碳张力变化对脑组织细胞内pH值的影响。使用31P核磁共振波谱法监测pH值变化，该方法在全身1.5特斯拉西门子成像系统上进行。测量在过度通气期间以及受试者呼吸含5体积%和7体积%二氧化碳的大气时进行。在15分钟的过度通气期间，细胞内pH值显著升高，而在呼吸含7体积%二氧化碳的空气18分钟期间，细胞内pH值显著降低。估算了细胞内缓冲能力。这些结果表明，对二氧化碳的通气反应与细胞内液pH值的变化相关。
