Department of Midwifery, Faculty of Nursing and Midwifery, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Endocr Disord. 2019 Sep 2;19(1):93. doi: 10.1186/s12902-019-0420-1.
Obese women with polycystic ovary syndrome (PCOS) may face additional barriers in achieving weight loss. We aimed to compare the effects of the hypocaloric low glycemic index (LGI) diet on anthropometric variables and insulin resistance in women with and without PCOS and investigate the effect of this diet on the clinical and hormonal features of PCOS women.
This interventional study was carried out at the Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Of 108 women invited for the purpose of the present study, 62 participants (PCOS = 28, non-PCOS = 34) followed a 24-week energy restricted LGI diet. Anthropometric, biochemical, hormonal and clinical measurements were documented at baseline, 12 weeks and 24 weeks with intervention.
The percentages of weight loss achieved by both the PCOS and non-PCOS groups did not differ significantly (PCOS: -8.04% vs. non-PCOS: -8.09%). No significant difference in decrease of homeostatic model assessment of insulin resistance (HOMA-IR) was observed between the two groups (PCOS = - 0.83 ± 0.33, non PCOS = - 0.79 ± 0.28, P = 0.83). In PCOS women, significant reduction in total testosterone (- 0.91 ± 0.33 nmol/L, P = 0.006), FAI (- 4.47 ± 1.1, P < 0.001) and increase in SHBG (38.98 ± 11.02 nmol/L, P < 0.001) were observed. Menstrual irregularity was improved in 80% of women with PCOS and a significant decrease (32.1%) in occurrence of acne was reported.
This diet has equally beneficial effects on anthropometric and metabolic characteristics of overweight women with and without PCOS.
This study is registered in the Iranian Randomized Clinical Trials Registry (IRCT, code: IRCT2016092129909N1 ).
患有多囊卵巢综合征（PCOS）的肥胖女性在减肥方面可能面临额外的障碍。我们旨在比较低热量低血糖指数（LGI）饮食对有和没有 PCOS 的女性的人体测量学变量和胰岛素抵抗的影响，并研究这种饮食对 PCOS 女性的临床和激素特征的影响。
这项干预性研究在伊朗沙希德贝赫什提大学医学科学研究所内分泌科学研究中心进行。在本研究中，共有 108 名女性受邀参加，其中 62 名参与者（PCOS=28，非 PCOS=34）遵循 24 周的能量限制 LGI 饮食。在干预前、12 周和 24 周记录人体测量学、生化、激素和临床测量值。
PCOS 组和非 PCOS 组的体重减轻百分比没有显著差异（PCOS：-8.04% vs. 非 PCOS：-8.09%）。两组之间 HOMA-IR 的降低没有显著差异（PCOS：-0.83±0.33，非 PCOS：-0.79±0.28，P=0.83）。在 PCOS 女性中，总睾酮（-0.91±0.33 nmol/L，P=0.006）、FAI（-4.47±1.1，P<0.001）显著降低，SHBG 增加（38.98±11.02 nmol/L，P<0.001）。80%的 PCOS 女性月经不规律得到改善，痤疮发生率显著下降（32.1%）。
这种饮食对超重有和没有 PCOS 的女性的人体测量学和代谢特征都有同样有益的影响。
本研究在伊朗随机临床试验注册中心（IRCT，注册号：IRCT2016092129909N1）注册。
