马拉开波的急性链球菌感染后肾小球肾炎。II：循环抗免疫球蛋白的发生率、性质及意义的研究
Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins.
作者信息
McIntosh R M, Rabideau D, Allen J E, Garcia R, Rubio L, Carr R I, Rodriguez-Iturbe B
出版信息
Ann Rheum Dis. 1979 Jun;38(3):257-61. doi: 10.1136/ard.38.3.257.
Antiglobulins were measured in the sera of 82 patients with acute poststreptococcal glomerulonephritis and correlated with C1q binding activity, serum levels of immunoglobulins and C3, site of infection, antibody titres to streptococcal enzymes, and the duration of the nephritis and interval from infection. Raised serum antiglobulins were found in 89.2% of the patients. In addition, raised titres were detected at any time during the course of the disease and very early after streptococcal infection. The finding of antiglobulins soon after the infection suggests the possibility that they appear as a primary event in the disease.
检测了82例急性链球菌感染后肾小球肾炎患者血清中的抗球蛋白，并将其与C1q结合活性、免疫球蛋白和C3的血清水平、感染部位、抗链球菌酶抗体滴度、肾炎病程以及感染后的间隔时间进行了关联分析。89.2%的患者血清抗球蛋白升高。此外，在疾病过程中的任何时候以及链球菌感染后很早就能检测到滴度升高。感染后不久就发现抗球蛋白，这表明它们可能是该疾病的原发性事件。
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