来自土壤源真菌PSU-SPSF346的倍半萜类化合物。
Sesquiterpenes from the soil-derived fungus PSU-SPSF346.
作者信息
Yaosanit Wiriya, Rukachaisirikul Vatcharin, Phongpaichit Souwalak, Preedanon Sita, Sakayaroj Jariya
机构信息
Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
出版信息
Beilstein J Org Chem. 2022 Apr 29;18:479-485. doi: 10.3762/bjoc.18.50. eCollection 2022.
Two new sesquiterpenes, trichocitrinovirenes A () and B (), and five known compounds including four structurally related sesquiterpenes and one γ-lactone were isolated from the soil-derived fungus PSU-SPSF346. The structures were identified by analysis of their spectroscopic data. The relative configuration was assigned based on NOEDIFF data. The absolute configuration of compound was established according to specific rotations and ECD data while that of compound was proposed based on biosynthetic considerations. Compound possesses a rare bicyclic sesquiterpene skeleton. The antimicrobial and cytotoxic activities of the isolated compounds were evaluated.
从土壤来源的真菌PSU - SPSF346中分离出两种新的倍半萜，即曲霉柠檬病毒A（）和B（），以及五种已知化合物，包括四种结构相关的倍半萜和一种γ-内酯。通过对其光谱数据的分析确定了结构。基于NOEDIFF数据指定了相对构型。根据比旋光度和ECD数据确定了化合物的绝对构型，而化合物的绝对构型则基于生物合成考虑提出。化合物具有罕见的双环倍半萜骨架。对分离出的化合物的抗菌和细胞毒性活性进行了评估。
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