上海浦东新区良性前列腺增生伴膀胱过度活动症的流行情况调查及其对健康相关生活质量的影响。
Epidemic investigation of benign prostatic obstruction with coexisting overactive bladder in Shanghai Pudong New Area and its impact on the health-related quality of life.
机构信息
Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.
出版信息
BMC Urol. 2019 Sep 3;19(1):82. doi: 10.1186/s12894-019-0513-1.
BACKGROUND
We aimed to investigate the prevalence, relative risk factors, and the impact on the health-related quality of life (HRQoL) of benign prostatic obstruction (BPO) with coexisting overactive bladder (OAB) in men aged over 50 and living in Shanghai Pudong New Area.
METHODS
Using a multi-stage sampling and descriptive epidemiological method, 1632 men were selected from among the general population. Participants completed an evaluation of lower urinary tracts symptoms (LUTS), including international prostate symptom score (IPSS) and quality of life (QoL) questionnaires. Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5) questionnaire. In addition, the Overactive Bladder Symptom Score (OABSS) and King's health questionnaire (KHQ) were used to assess the impact of BPO with coexisting OAB on the HRQoL. Maximum flow rate (Q), postvoid residual urine volume (PVR) and prostate-specific antigen (PSA) were also recorded.
RESULTS
A total of 1476 men with complete data were analyzed. The overall prevalence of BPO with coexisting OAB was 39.6%. Age and prostate volume were associated risk factors for BPO with coexisting OAB. In addition, BPO with coexisting OAB negatively impacted the HRQoL, with increased IPSS, QoL, OABSS, and KHQ scores and decreased IIEF-5 scores compared to that in patients with BPO without OAB.
CONCLUSIONS
Q, PVR and serum PSA did not predict whether the patients had a combined BPO + OAB or not. The prostate volume and age were associated risk factors for BPO with coexisting OAB. BPO is a progressive disease and may be one of the risk factors for OAB.
背景
本研究旨在调查上海浦东新区 50 岁以上男性良性前列腺增生（BPO）合并膀胱过度活动症（OAB）的患病率、相对危险因素及对健康相关生活质量（HRQoL）的影响。
方法
采用多阶段抽样和描述性流行病学方法，从普通人群中选择 1632 名男性。参与者完成了下尿路症状（LUTS）评估，包括国际前列腺症状评分（IPSS）和生活质量（QoL）问卷。采用国际勃起功能指数-5（IIEF-5）问卷评估勃起功能。此外，还使用膀胱过度活动症症状评分（OABSS）和 King 健康问卷（KHQ）评估 BPO 合并 OAB 对 HRQoL 的影响。还记录了最大尿流率（Q）、残余尿量（PVR）和前列腺特异性抗原（PSA）。
结果
共分析了 1476 名数据完整的男性。BPO 合并 OAB 的总患病率为 39.6%。年龄和前列腺体积是 BPO 合并 OAB 的相关危险因素。此外，BPO 合并 OAB 对 HRQoL 产生负面影响，与单纯 BPO 患者相比，IPSS、QoL、OABSS 和 KHQ 评分升高，IIEF-5 评分降低。
结论
Q、PVR 和血清 PSA 并不能预测患者是否同时患有 BPO 和 OAB。前列腺体积和年龄是 BPO 合并 OAB 的相关危险因素。BPO 是一种进行性疾病，可能是 OAB 的危险因素之一。
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