Department of Pharmacology, Faculty of Pharmacy, Jinnah Sindh Medical University, Rafiqui H.J Shaheed Road, Karachi, 75510, Pakistan.
Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
BMC Complement Altern Med. 2019 Sep 3;19(1):236. doi: 10.1186/s12906-019-2661-y.
Syzygium cumini (L.) Skeels. is one of the very popular traditionally used medicinal plants with numerous pharmacological activities including antioxidant, hypoglycemic and anti-inflammatory. However, actions of S. cumini on blood coagulation and other parameters of blood were poorly pharmacologically studied. Therefore, aim of this present investigation is to examine the effects of methanolic extract of S. cumini on blood coagulation and anticoagulation factors in healthy white albino rabbits at different doses.
Blood samples were drawn twice during this study and biochemical assays were performed to determine the effect on different parameters such as coagulation, anticoagulation, hematological, Protein C (PC) and thrombin antithrombin (TAT) complex and platelet aggregation.
The results showed significant increase in RBCs, hemoglobin, hematocrit and platelets counts up to 1.4 × 10/cm, 2.2 g/dl, 6%, 248.2 × 10/cm respectively. While, thrombin and bleeding time were also prolonged in dose dependent manner which is highly significant (p ≤ 0.005) as compared to control. Similarly, highly significantly increased (p ≤ 0.005) in levels of protein C, thrombin antithrombin complex at dose of 500 mg/kg were observed. Whereas, levels of platelets aggregation and fibrinogen were decreased at high doses.
The obtained findings of hematological and coagulation tests concludes possibly S. cumini possess anticoagulant and antiplatelet effects.
Syzygium cumini（L.）Skeels. 是一种非常受欢迎的传统药用植物，具有多种药理活性，包括抗氧化、降血糖和抗炎作用。然而，S. cumini 对凝血和血液其他参数的作用在药理学上研究甚少。因此，本研究旨在考察不同剂量的 S. cumini 甲醇提取物对健康白兔凝血和抗凝因子的影响。
在本研究中两次抽取血液样本，并进行生化分析，以确定对不同参数的影响，如凝血、抗凝、血液学、蛋白 C（PC）和凝血酶抗凝血酶（TAT）复合物以及血小板聚集。
结果表明，红细胞、血红蛋白、血细胞比容和血小板计数分别显著增加至 1.4×10/cm、2.2g/dl、6%和 248.2×10/cm。同时，凝血酶和出血时间也呈剂量依赖性延长，与对照组相比具有高度显著性（p≤0.005）。同样，在 500mg/kg 剂量下，蛋白 C 和凝血酶抗凝血酶复合物的水平也显著升高（p≤0.005）。然而，在高剂量下，血小板聚集和纤维蛋白原的水平降低。
血液学和凝血试验的结果表明，S. cumini 可能具有抗凝和抗血小板作用。
