非洲崖豆木（史密斯）茎皮水提取物对链脲佐菌素诱导的糖尿病Wistar大鼠的抗糖尿病和血液学作用
Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin-induced diabetic Wistar rats.
作者信息
Oyedemi S O, Adewusi E A, Aiyegoro O A, Akinpelu D A
机构信息
School of Biological Sciences, University of Fort Hare, Alice 5700, South Africa.
出版信息
Asian Pac J Trop Biomed. 2011 Oct;1(5):353-8. doi: 10.1016/S2221-1691(11)60079-8.
OBJECTIVE
To investigate the antidiabetic properties of aqueous extract of stem bark of Afzelia africana (A. africana) and its beneficial effect on haematological parameters in streptozotocin induced diabetic rats.
METHODS
A total of 30 rats including 24 diabetic and 6 normal rats were used for this study. Diabetes was induced in male Wistar rats by intraperitoneal injection of streptozotocin. After being confirmed diabetic, animals were orally treated with distilled water or extracts at 100 or 200 mg/kg body weight daily for 10 days. The haematological parameters including red blood and white blood cells and their functional indices were evaluated in diabetic treated groups compared with the controls.
RESULTS
The extract significantly reduced the blood glucose levels while the best result was obtained at 200 mg/kg body weight. The feed and water intake in diabetic rats were significantly reduced while weight loss was minimized at both dosages. Similarly, the levels of red blood, white blood cells and their functional indices were significantly improved after extract administration at both doses.
CONCLUSIONS
It can be concluded that the aqueous extract of bark of A. africana possesses antihyperglycemic properties. In addition, the extract can prevent various complications of diabetes and improve some haematological parameters. Further experimental investigation is needed to exploit its relevant therapeutic effect to substantiate its ethnomedicinal usage.
目的
研究非洲崖豆木茎皮水提取物的抗糖尿病特性及其对链脲佐菌素诱导的糖尿病大鼠血液学参数的有益影响。
方法
本研究共使用30只大鼠，其中包括24只糖尿病大鼠和6只正常大鼠。通过腹腔注射链脲佐菌素诱导雄性Wistar大鼠患糖尿病。确认糖尿病后，动物每天口服蒸馏水或100或200毫克/千克体重的提取物，持续10天。与对照组相比，评估糖尿病治疗组的血液学参数，包括红细胞和白细胞及其功能指标。
结果
提取物显著降低了血糖水平，在200毫克/千克体重时效果最佳。糖尿病大鼠的饲料和水摄入量显著减少，两种剂量下体重减轻均最小化。同样，两种剂量的提取物给药后，红细胞、白细胞水平及其功能指标均得到显著改善。
结论
可以得出结论，非洲崖豆木树皮水提取物具有降血糖特性。此外，该提取物可以预防糖尿病的各种并发症并改善一些血液学参数。需要进一步的实验研究来开发其相关治疗效果，以证实其民族药用用途。
Zotero 插件