The Transcription Factor Regulates the Susceptibility of to Abamectin via .

Pesticide resistance is a serious problem that poses a major challenge to pest control. One of the most potent resistance mechanisms is the overexpression of genes coding for detoxification enzymes. The expression of detoxification genes is regulated by a series of transcription factors. Previous studies have revealed that the increased expression of detoxification genes contributes to the insecticide tolerance of Our objective was thus to identify the transcription factors involved in this process. Temporal expression profiles showed that the transcription factor and detoxification genes were expressed highly in the fat body. Further analysis showed that the expression of , , and was induced by abamectin. Disruption of the transcription factor through RNA interference decreased the transcript levels of and and increased the susceptibility to abamectin significantly. Direct silencing of the expression of also increased susceptibility to abamectin, while did not. In conclusion, these results suggest that the expression of and was regulated by the transcription factor , and the up-regulation of via decreased the susceptibility of to abamectin.