J Agric Food Chem. 2019 Sep 25;67(38):10667-10677. doi: 10.1021/acs.jafc.9b04792. Epub 2019 Sep 16.
This study investigated the modulatory effects of seed oil (DISO), which was rich in palmitoleic acid (55.25%), palmitic acid (12.25%), and oleic acid (28.74%), on alcohol-induced metabolism disorder in mice. Fifty mice were orally administered with 38% alcohol (0.4 mL/day) and without or with DISO (3, 6, and 12 g/kg) for consecutive 12 weeks. DISO inhibited the alcohol-induced weight loss and liver function abnormality ( < 0.01) and shifted the profiles of cecal microbiome: elevating the abundance of , __004 ( < 0.05) and decreasing abundance of ( < 0.05). This treatment also regulated metabolome response of amino acid and lipid metabolism in cecal content: upregulating 5-hydroxyindole-3-acetic acid ( < 0.05), 6-hydroxynicotinic acid, 5-methoxytryptamine, nicotinamide, and nicotinic acid ( < 0.1) and downregulating androsterone, tryptophan, and indole-3-acetamide ( < 0.05). DISO protected against alcoholic liver injury and gut microbiota dysbiosis by enriching the relative abundance of , which was positively associated with the improvement of intestinal permeability and tryptophan metabolism.
本研究探讨了富含棕榈油酸（55.25%）、棕榈酸（12.25%）和油酸（28.74%）的 种子油（DISO）对小鼠酒精诱导的代谢紊乱的调节作用。50 只小鼠连续 12 周每天口服 38%酒精（0.4 mL/天）和/或 DISO（3、6 和 12 g/kg）。DISO 抑制了酒精引起的体重减轻和肝功能异常（<0.01），并改变了盲肠微生物组的特征：增加了 的丰度，__004（<0.05）和减少了 的丰度（<0.05）。这种治疗还调节了盲肠内容物中氨基酸和脂质代谢的代谢组学反应：上调 5-羟色胺-3-乙酸（<0.05）、6-羟基烟酸、5-甲氧基色胺、烟酰胺和烟酸（<0.1），下调雄酮、色氨酸和吲哚-3-乙酰胺（<0.05）。DISO 通过富集与肠道通透性和色氨酸代谢改善呈正相关的相对丰度，从而防止酒精性肝损伤和肠道微生物失调。
