College of Food Science, Southwest University, Beibei, Chongqing 400715, China.
Nutrients. 2022 Sep 5;14(17):3662. doi: 10.3390/nu14173662.
Hawk tea ( Levl. var. ) is a traditional herbal tea in southwestern China, and was found to possess hepatoprotective effects in our previous study. However, it is unclear whether hawk tea flavonoids (HTF) can alleviate alcoholic liver damage (ALD). Firstly, we extracted and identified the presence of 191 molecules categorized as HTFs, with reynoutrin, avicularin, guaijaverin, cynaroside, and kaempferol-7-O-glucoside being the most prevalent. After taking bioavailability into consideration and conducting comprehensive sorting, the contribution of guaijaverin was the highest (0.016 mg/mice). Then, by daily intragastric administration of HTF (100 mg/kg/day) to the ALD mice, we found that HTF alleviated liver lipid deposition (inhibition of TG, TC, LDL-C) by reducing liver oxidative-stress-mediated inflammation (up-regulation NRF2/HO-1 and down-regulation TLR4/MyD88/NF-κB pathway) and reshaping the gut microbiota (Lactobacillus, Bifidobacterium, Bacillus increased). Overall, we found HTF could be a potential protective natural compound for treating ALD via the gut-liver axis and guaijaverin might be the key substance involved.
老鹰茶（变种）是中国西南地区的一种传统草本茶，在我们之前的研究中发现它具有护肝作用。然而，目前尚不清楚老鹰茶类黄酮（HTF）是否可以缓解酒精性肝损伤（ALD）。首先，我们提取并鉴定了 191 种分类为 HTF 的分子，其中以瑞香素、圣草酚-7-O-葡萄糖苷、芫花素、槲皮苷和川陈皮素最为常见。在考虑生物利用度并进行全面分类后，发现芫花素的贡献最高（0.016mg/mice）。然后，通过每日灌胃给予 ALD 小鼠 HTF（100mg/kg/天），我们发现 HTF 通过减轻肝氧化应激介导的炎症（上调 NRF2/HO-1 和下调 TLR4/MyD88/NF-κB 通路）和重塑肠道微生物群（增加乳杆菌、双歧杆菌和芽孢杆菌）来缓解肝脂质沉积（抑制 TG、TC、LDL-C）。总的来说，我们发现 HTF 可以通过肠肝轴成为治疗 ALD 的潜在天然保护化合物，而芫花素可能是涉及的关键物质。
