在小鼠视觉皮层中，用于跨视域图的γ波段相干性的神经回路。
A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex.
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, United States.
Helen Wills Neuroscience Institute, University of California, Berkeley, United States.
出版信息
Elife. 2018 Feb 26;7:e28569. doi: 10.7554/eLife.28569.
Cortical gamma oscillations have been implicated in a variety of cognitive, behavioral, and circuit-level phenomena. However, the circuit mechanisms of gamma-band generation and synchronization across cortical space remain uncertain. Using optogenetic patterned illumination in acute brain slices of mouse visual cortex, we define a circuit composed of layer 2/3 (L2/3) pyramidal cells and somatostatin (SOM) interneurons that phase-locks ensembles across the retinotopic map. The network oscillations generated here emerge from non-periodic stimuli, and are stimulus size-dependent, coherent across cortical space, narrow band (30 Hz), and depend on SOM neuron but not parvalbumin (PV) neuron activity; similar to visually induced gamma oscillations observed in vivo. Gamma oscillations generated in separate cortical locations exhibited high coherence as far apart as 850 μm, and lateral gamma entrainment depended on SOM neuron activity. These data identify a circuit that is sufficient to mediate long-range gamma-band coherence in the primary visual cortex.
皮层γ 振荡与多种认知、行为和电路水平现象有关。然而，γ 波段在皮层空间的产生和同步的电路机制仍不确定。我们使用光遗传学模式化照明，在急性小鼠视觉皮层脑片中定义了一个由 2/3 层（L2/3）锥体神经元和生长抑素（SOM）中间神经元组成的电路，该电路使视域图上的集合相位锁定。这里产生的网络振荡来自非周期性刺激，与刺激大小有关，在皮层空间上具有相干性，带宽较窄（30 Hz），并且依赖于 SOM 神经元而非钙结合蛋白（PV）神经元的活动；类似于在体内观察到的视觉诱导的γ 振荡。在相隔 850 μm 的不同皮层位置产生的γ 振荡具有很高的相干性，并且γ 侧同步取决于 SOM 神经元的活动。这些数据确定了一个足以介导初级视觉皮层长程 γ 波段相干性的电路。
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